泽泻提取物对正常及四氧嘧啶小鼠糖尿病模型的影响

目的 :研究泽泻水提醇沉法提取物 (RAE)的抗糖尿病作用。方法 :给小鼠尾静脉注射四氧嘧啶 90mg·kg- 1 ,造成糖尿病模型。测定血糖 (Glu)、甘油三酯 (Trig)、胆固醇 (Chol)、胰淀粉酶 (Amy)和血清胰岛素 (Ins)。光镜下观察胰腺和胰岛的组织学变化。结果 :RAE可使正常小鼠血糖明显降低。治疗 7天可使四氧嘧啶小鼠Glu和Trig降低。光镜下观察RAE治疗后的四氧嘧啶小鼠 ,胰岛保持正常组织学形态。RAE还可升高血清Ins水平及对抗四氧嘧啶诱发的Amy降低。

Effect of Extract from Rhizoma Alismatis on Normal and Alloxan Model in Mice

Mice were injected with alloxan,90mg/kg,introcaudal veins,to induce diabetes.Blood glucose(Glu),triglyceride(Trig),cholesterol(Chol)and pancreatic amylase(Amy)were determined by using Automatic Biochemistry Analysor,and serum insulin(Ins) was determined by radioimmunoassay,the pathological examinations of pancreas and islets wee observed under light microscope.Results showed:RAE,3\^0g/kg ig,reduced the bolld glucose in normal mice after a single administration.RAE(1\^5,3\^0g/kg ig)also decreased Glu and Trig after administration for 7 days in alloxan-induced hyperglycemic mice.Pathological examination manifested approximate normal pathology distinction in RAE-treated group.RAE also increased the release of INS,and was able to arise the lowered Amy in diabetic mice.