Serum uric acid is independently associated with aortic arch calcification in a cross-sectional study of middle-aged and elderly women |
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| Affiliation: | 1. Division of Rheumatology, The First Affiliated Hospital of Nanjing Medical University, China;2. Division of Rheumatology, The Affiliated Changzhou NO.2 People''s Hospital of Nanjing Medical University, China;3. Division of Rheumatology, Yancheng First Hospital, Jiangsu Province, China;4. Institute of Integrated Chinese and Western Medicine, Nanjing Medical University, China;5. Division of Cardiology, The First Affiliated Hospital of Nanjing Medical University, China;2. Nagoya First Red Cross Hospital, Nagoya, Japan;3. Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan,;4. Nagoya University Graduate School of Health Science, Nagoya, Japan;1. Division of Rheumatology, Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA;2. Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA;3. Division of General Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA;4. Department of Radiology, Mayo Clinic College of Medicine, 200 1st St SW, Rochester, MN 55905, USA;1. 3rd Department of Cardiology, SMDZ in Zabrze, Medical University of Silesia, Katowice, Poland;2. Student''s Scientific Society, 3rd Department of Cardiology, SMDZ in Zabrze, Medical University of Silesia, Katowice, Poland;3. Department of Biostatistics, SPH in Bytom, Medical University of Silesia, Katowice, Poland;4. Department of Anesthesiology, SMDZ in Zabrze, Medical University of Silesia, Katowice, Poland;5. Department of Cardiosurgery, Transplantology, Vascular and Endovascular Surgery, SMDZ in Zabrze, Medical University of Silesia, Katowice, Poland |
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| Abstract: | Background and aimsThe increased serum uric acid (SUA) level is associated with the prevalence of cardiovascular disease (CVD) risks. Aortic arch calcification (AAC) reflects subclinical coronary atherosclerosis and is linked to subsequent cardiovascular morbidity and mortality risks closely. To better understand the role of SUA on arteriosclerosis and CVD, we aim to determine the association between SUA and the presence of AAC.Methods and resultsA total of 5920 individuals aged >45 years old without prior CVD disease were included. The prevalence rate of AAC was 14.4% in all participants and a significantly increasing trend for AAC prevalence rate was found across the SUA tertiles (p < 0.001 for trend). Subsequent subgroup analyses revealed that this positive association trend was only significant in female subjects. After adjusting for confounders, SUA is an independent predictor for the presence of AAC in overall participants and in women.ConclusionSUA is independently associated with AAC in middle-aged and elderly population, especially in the women. More research needs to determine whether lower thresholds for CVD risk screening for those middle-aged and elderly women with higher SUA tertile even without hyperuricemia are warranted. |
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| Keywords: | Serum uric acid Aortic arch calcification Middle-aged and elderly population |
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