| 硫丹对长爪沙鼠血细胞免疫相关因子表达的影响 |
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| 引用本文： | 杨蕾蕾,张濛,周显青,王迎.硫丹对长爪沙鼠血细胞免疫相关因子表达的影响[J].实验动物科学,2011,28(2):27-30,43. |
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| 作者姓名： | 杨蕾蕾 张濛 周显青 王迎 |
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| 作者单位： | 1. 首都医科大学基础医学院实验动物学系,北京,100069
2. 首都医科大学基础医学院实验动物学系,北京,100069;首都医科大学公共卫生与家庭医学学院卫生毒理学与卫生化学系,北京,100069 |
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| 基金项目： | 国家自然科学基金课题资助(No.30970454)环境激素硫丹对长爪沙鼠和小鼠红细胞免疫功能的影响及机制的研究 |
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| 摘 要： | 目的 探讨有机氯农药硫丹对长爪沙鼠血细胞免疫功能相关因子的影响。方法将50只长爪沙鼠随机分成5组，各组动物所用硫丹灌胃的剂量依次为：0mg／（kg·d）、0．4mg／（kg·d）、0．8mg／（kg·d）、1．6mg／（kg·d）和6．4mg／／（kg·d）。灌胃21d后，取血检测血细胞免疫功能相关因子的表达。结果药物处理后，红细胞表面CD59因子和B淋巴细胞表面CD35因子的表达量在各实验组和对照组间没有明显差异（P〉0．05）。红细胞膜表面CD58因子随硫丹浓度的升高显著下降，0．8mg,／（kg·d）、1．6mg／（kg·d）和6．4／mg／（kg·d）组较对照组有显著降低（P〈0．05）。结论硫丹能抑制长爪沙鼠红细胞膜表面CD58因子表达，但对红细胞膜表面CD59和B细胞表面的CD35的表达没有影响。
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| 关 键 词： | 硫丹 长爪沙鼠 CD35 CD58 CD59 |
Effects of Endosulfan on the Blood Cell Immune Factors in Mongolian Gerbil |
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| YANG Lei-lei,ZHANG Meng,ZHOU Xian-qing,WAMG Ying.Effects of Endosulfan on the Blood Cell Immune Factors in Mongolian Gerbil[J].Shiyan Dongwu Kexue,2011,28(2):27-30,43. |
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| Authors: | YANG Lei-lei ZHANG Meng ZHOU Xian-qing WAMG Ying |
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| Affiliation: | YANG Lei-lei1,ZHANG Meng1,ZHOU Xian-qing1,2,WAMG Ying1(1.Department of Laboratory Animal Sciences,Capital Medical University,Beijing 100069,China)(2.School of Pubilc Health and Fmaily Medicine,China) |
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| Abstract: | Objective To investigate the effects of organ chlorine pesticide—endosulfan—on the blood cell immune factors in Mongolian gerbil we designed this experiment.Methods 50 Mongolian gerbils were randomly divided into 5 groups.They were gavaged endosulfan at levels of 0,0.4,0.8,1.6,and 6.4 mg /(kg.d),respectively.twenty one days later,blood was then collected to determine 3 of blood cell immune factors.Results (1) The expression levels of CD59 on erythrocyte membrane and CD35 on B lymphocyte membrane had no differences among the 5 groups(p > 0.05) after treatment;(2) The levels of CD58 on erythrocyte membrane gradually decreased with the increase of endosulfan dosage,and the three groups given endosulfan level at 0.8,1.6,6.4mg/(kg.d) were significantly lower than that of the control group(p < 0.05).Conclusion The results suggested that endosulfan can inhibit the express of CD58 on erythrocyte,but have no effect on the expression levels of CD59 on erythrocyte membrane and CD35 on B lymphocyte membrane. |
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| Keywords: | CD35 CD58 CD59 |
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