Tissue-specific accumulation of cadmium and its effects on antioxidative responses in Japanese flounder juveniles |
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Authors: | Cao Liang Huang Wei Shan Xiujuan Ye Zhenjiang Dou Shuozeng |
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Affiliation: | a Key Laboratory of Marine Ecology and Environmental Sciences, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, PR China b Laboratory of Marine Ecosystem and Biogeochemistry, Second Institute of Oceanography, State Oceanic Administration, Hangzhou 310012, PR China c Yellow Sea Fishery Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, PR China d Fishery College, Ocean University of China, Qingdao 266003, PR China |
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Abstract: | This study investigated the accumulation of cadmium (0-8 mg Cd L−1) and its toxicological effects on oxidative stress biomarkers in different tissues of Japanese flounder juveniles. Following Cd exposure for 28 d, accumulation of Cd in fish was dose-dependent and tissue-specific, with the greatest accumulation in the liver, followed by the kidney, gill, and muscle. Although the gill and liver mounted active antioxidant responses at ≥4 mg L−1 Cd including a decrease in glutathione level and GST and GPx activities, the antioxidant response failed to prevent lipid peroxidation induction in these organs. In the kidney, increased GPx and GST activities and decreased SOD activity were observed in fish exposed to high Cd concentrations, but LPO levels did not significantly differ among the exposure concentrations. The gill was most sensitive to oxidative damage, followed by the liver; the kidney was the least affected tissue. |
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Keywords: | Cd Antioxidants LPO Accumulation Japanese flounder |
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