眼睑松弛症的研究进展

眼睑松弛症是一种少见的眼睑疾病，多于青春期发病，以不明原因反复发作的间断性、无痛性、无红斑形成的眼睑皮肤血管神经性水肿为特征，导致眼睑皮肤松弛、萎缩变薄，后期并发上睑下垂、眶脂肪脱垂、泪腺脱垂、睑裂狭小等。至今其病因尚不明确，研究表明，可能与遗传、内分泌因素有关，但组织病理学检查见弹力纤维断裂溶解、IgA 沉积和炎症细胞浸润，因此推测免疫机制、炎症反应对疾病的发展可能起着重要作用。根据临床分期，目前有口服药物、手术两种治疗方式。

Diagnosis and treatment of the blepharochalasis

Blepharochalasis is a rare disease that often onsets in childhood or adolescence. It is characterized by non-painful, non-erythemaous eyelid angioedema with intermittent recurrent episodes, resulting in relaxation, atrophy and thinned of eyelid structures. The late complications, attributing to continuous underlying structural destruction, including ptosis, orbital fat prolapse, lacrimal glands prolapse and blepharophimosis etc. The pathogenesis is not clear yet, researchers have indicated that it might be associated with inheritance and endocrine factors. Nevertheless, histopathology examination showed elastic fibers breakdown, IgA deposits and inflammatory cell infiltration. Based on this, it is assumed that the immunologic mechanism and inflammatory reaction play a significant role in the development of the disease. According to the clinical stage, there are two treatment patterns: oral medicine and surgery at present.