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| 多重耐药鲍曼不动杆菌16S rRNA甲基化酶基因研究 | |
| 引用本文： | 梁军兵,潘君素,陈贤君,张春玲,周绮妮.多重耐药鲍曼不动杆菌16S rRNA甲基化酶基因研究[J].海峡药学,2011,23(5):68-71. |
| 作者姓名： | 梁军兵 潘君素 陈贤君 张春玲 周绮妮 |
| 作者单位： | 1. 浙江省台州市中心医院检验科,台州,318000 2. 浙江省台州市立医院呼吸科,台州,318000 3. 浙江省台州市中心医院药剂科,台州,318000 |
| 基金项目： | 浙江省台州市科技局基金项目 |
| 摘 要： | 目的 调查临床分离多重耐药鲍曼不动杆菌中介导氨基糖苷类高水平耐药的16S rRNA甲基化酶基因armA、rmtA、rmtB的流行情况.方法 收集台州市中心医院、台州市立医院两家多重耐药鲍曼不动杆菌128抹,用K-B法测定18种抗菌药物;采用琼脂稀释法测定4种氨基糖苷类药物MIC值;PCR检测armA、rmtA、rmtB... |
| 关 键 词： | 氨基糖苷类 16S rRNA甲基化酶 鲍曼不动杆菌 |
Study on 16S rRNA methylase genes in Multidrug-resistant Strains of acinetobacter baumannii |
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| LIANG Jun-bing,PAN Jun-su,OHEN Xian-jun,ZHANG Chun-ling,ZHOU Qi-ni.Study on 16S rRNA methylase genes in Multidrug-resistant Strains of acinetobacter baumannii[J].Strait Pharmaceutical Journal,2011,23(5):68-71. | |
| Authors: | LIANG Jun-bing PAN Jun-su OHEN Xian-jun ZHANG Chun-ling ZHOU Qi-ni |
| Affiliation: | 1.Center of Clinical Laboratory,Taizhou Center Hospital,Zhejiang 318000,China;2.Department of Respiratory,Taizhou Municipal Hospital Taizhou,Zhejiang 318000,China) |
| Abstract: | OBJECTIVE To investigate the prevalence of 16S rRNA methylases genes,armA,rmtA and rmtB,which mediate high level aminoglycoside resistance in Acinetobacter baumannii isolates.METHODS A total of 128 Multidrug-resistant strains of bacter baumannii were collected from 2 hospitals of Taizhou.The minimum inhibitory concentrations(MIC)were examined by agar dilution method.Three 16S rRNA methylase genes,armA,rmtA and rmtB,were detected by PCR.PCR products were purified and sequenced.RESULTS The positive rates of armA were 34.3% from 128 Multidrug-resistant strains of bacter baumannii,no rmtA,rmtB gene was detected.CONCLUSION ArmA producing Acinetobacter baumannii isolates are detected in Taizhou.which can mediate high-level resistance to aminoglycosides,but also the multiple-resistances to other many kinds of antibiotics. |
| Keywords: | Aminoglycoside 16S rRNA methylases Acinetobacter baumanii |
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