| p38蛋白激酶(p38 MAPK)在癫疒间大鼠脑内的表达 |
| |
| 引用本文： | 王翠翠,陈英辉.p38蛋白激酶(p38 MAPK)在癫疒间大鼠脑内的表达[J].复旦学报(医学版),2013,40(4):419-422. |
| |
| 作者姓名： | 王翠翠 陈英辉 |
| |
| 作者单位： | 1复旦大学附属金山医院神经内科上海201508;2复旦大学上海医学院神经病学系上海200032 |
| |
| 基金项目： | 上海市卫生局局级科研项目(2008080);上海市自然科学基金项目(09ZR1405500)~~ |
| |
| 摘 要： | 目的 观察p38蛋白激酶(p38 mitogen-activated protein kinase,p38 MAPK)在癫疒间大鼠脑内的表达情况。方法 健康雄性SD大鼠随机分成正常对照组(n=8)和癫疒间组(n=8)。采用戊四氮腹腔注射建立癫疒间模型,大鼠点燃后的惊厥行为按照Racine的标准进行观察评分,采用Western blot和免疫荧光法比较两组大鼠脑内p38 MAPK的表达情况。结果 癫疒间组大鼠脑内p38 MAPK在皮层和海马的表达均显著高于正常对照组(P<0.01)。结论 p38 MAPK在癫疒间大鼠脑内表达上调。
|
| 关 键 词： | p38蛋白激酶(p38 MAPK) 癫疒间 戊四氮 P-糖蛋白 大鼠 |
The expression of p38 mitogen-activated protein kinase (p38 MAPK) in cerebra of rat with epilepsy |
| |
| WANG Cui-cui,CHEN Ying-hui.The expression of p38 mitogen-activated protein kinase (p38 MAPK) in cerebra of rat with epilepsy[J].Fudan University Journal of Medical Sciences,2013,40(4):419-422. |
| |
| Authors: | WANG Cui-cui CHEN Ying-hui |
| |
| Affiliation: | 1Department of Neurology,Jinshan Hospital,Fudan University,Shanghai 201508,China;
2Department of Neurology,Shanghai Medical College,Fudan University,Shanghai 200032,China |
| |
| Abstract: | Objective To investigate the expression of p38 mitogen-activated protein kinase (p38 MAPK) in cerebra of rat with epilepsy.Methods Healthy male SD rats were randomly divided into normal (n=8) and epileptic group (n=8).Epilepsy model was established with the intraperitoneal injection of pentylenetetrazol.Behaviors were classified according to the criteria of Racine.The expression of p38 MAPK in cerebra was observed by immunofluorescence and Western blot.Results Compared with the normal rats,the expression of p38 MAPK in cortex and hippocampus of epileptic rats was significantly higher (P<0.01).Conclusions The expression of p38 MAPK was up-regulated in cerebra of epileptic rats. |
| |
| Keywords: | p38 mitogen-activated protein kinase (p38 MAPK) epilepsy pentylenetetrazol P-glycoprotein rat |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《复旦学报(医学版)》浏览原始摘要信息 |
|
点击此处可从《复旦学报(医学版)》下载全文 |
