安体舒通对老年单纯收缩期高血压的作用

目的 观察安体舒通对老年单纯收缩期高血压(ISH)患者的影响。方法ISH患者56例，随机分为对照组和治疗组，对照组以硝苯地平控释片30mg，d口服，治疗组在硝苯地平控释片30mg/d口服基础上加用安体舒通60mg/d口服，观察1年。应用偶测血压及动态血压监测参数比较二药对老年ISH血压及其节律的影响。结果二药均可以降低收缩压改善血压节律，但治疗组的作用更显著且能更好地降低脉压。结论安体舒通能降低ISH患者的SBP，显著改善异常的血压节律，有益于老年ISH患者减轻靶器官损害，降低心血管疾病的风险。

Effect of spironolactone on simple systolic hypertension in the elderly

Objective To investigate the therapeutic effect of spironolactone on isolated systolic hypertension (ISH) in the elderly.Methods Fifty-six patients were randomly divided into two groups.30 patients in control group were treated with nifedipine (Gis 30 mg/d);26 patients in treatment group were treated with nifedipine (Gits 30 mg/d) combined with spironolactone (60 mg/d),with a treatment course of 12 months for both groups.The parameters of ambulatory blood pressure and office blood pressure were observed and compared between two groups.Results Both drugs could decrease systolic pressure and improve blood pressure rhythm,however,the effect in treatment group was more obvious than that of control group,and which could obviously decrease pulse pressure.Conclusion Spironolactone can decrease SBP in ISH patients and improve blood pressure rhythm,and can relieve the damage of target organs and reduce the risk of cardiovascular diseases.