| 载脂蛋白E基因多态性与缺血性卒中 |
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| 引用本文： | 杨赟,许虹.载脂蛋白E基因多态性与缺血性卒中[J].国外医学：脑血管疾病分册,2013(9):693-696. |
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| 作者姓名： | 杨赟 许虹 |
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| 作者单位： | 昆明医科大学第一附属医院神经内科,650032 |
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| 摘 要： | 载脂蛋白E（apolipoprotein E,ApoE）具有基因多态性（ε2、ε3和ε4）.业已证实,ApoE结构和功能异常与高脂血症和动脉粥样硬化的形成及其严重程度密切相关,而高脂血症和动脉粥样硬化均为缺血性卒中的危险因素.近年来,虽然对ApoE基因多态性与缺血性卒中的关系进行了广泛研究,但结论并不一致.文章就ApoE基因多态性与缺血性卒中相关性的研究进行了综述.
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| 关 键 词： | 卒中 脑缺血 载脂蛋白E 多态现象 遗传学 |
Apolipoprotein E gene polymorphism and ischemic stroke |
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| YANG Yun,XU Hong.Apolipoprotein E gene polymorphism and ischemic stroke[J].Foreign Medical Sciences Cerebrovascular Diseases,2013(9):693-696. |
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| Authors: | YANG Yun XU Hong |
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| Affiliation: | (Department of Neurology, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, China) |
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| Abstract: | Apolipoprotein E （ApoE） has gene polymorphism （ε2,ε3,and ε4）.It has been confirmed that ApoE structural and functional abnormlities are closely associated with the hyperlipidemia,formation of atherosclerosis,and its severity,while both hyperlipidemia and atherosclerosis are the risk factors for ischemic stroke.In recent years,although the relationship between the ApoE gene polymorphism and ischemic stroke has been extensively studied,the conclusions are not consistent.This article reviews the correlation studies between the ApoE gene polymorphism and ischernic stroke. |
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| Keywords: | Stroke Brain Ischemia Apolipoproteins E Polymorphism Genetic |
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