Cerebrospinal fluid analysis of pregnant women at early stages of COVID-19 |
| |
| Affiliation: | 1. Department of Obstetrics and Gynecology, University of Brasília, Brasília, Brazil;2. Postgraduate Program in Medical Sciences, University of Brasília, Brasília, Brazil;3. Department of Pediatrics, University of Brasília, Brasília, Brazil;4. Regional Hospital of Asa Norte, Health Department, Brasília, Brazil;5. Central Laboratory of Public Health of the Federal District, Brasília, Brazil |
| |
| Abstract: | ObjectiveTo determine the presence or absence of SARS-CoV-2 in the cerebrospinal fluid of pregnant women at early stages of COVID-19.Materials and methodsWe conducted a prospective observational study with pregnant women undergoing cesarean section and real-time polymerase chain reaction to SARS-CoV-2 was performed in the cerebrospinal fluid in the early stages of COVID-19.ResultsFourteen pregnant women, whose COVID-19 symptoms started between four to 18 days prior to delivery, were included. Eleven of the women reported anosmia, dysgeusia, and headaches and there were two fatal cases. SARS-Cov-2 was not present in the cerebrospinal fluid of these COVID-19 patients with early neurological symptoms, even in severe cases.ConclusionOur study suggests that peripheric cell damage and parainfectious phenomena may predominate over direct central nervous system injury in the pathophysiology of COVID-19 related early neurological symptoms on pregnant women. |
| |
| Keywords: | COVID-19 Inflammation Neurology Pregnancy SARS-CoV-2 |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
