双氯芬酸钠缓释微胶囊的制备与表征

以乙基纤维素为壁材，采用乳化-溶剂扩散技术制备双氯芬酸钠缓释微胶囊，通过考察包封率和载药量确定其制备工艺，并对微胶囊的形态和释放度等理化性能进行表征．结果表明，当有机相中乙基纤维素的质量浓度为3×10^-2g／mL，水相中乳化剂十二烷基硫酸钠的质量浓度为3×10^-3g／mL，双氯芬酸钠与乙基纤维素的投料比mEC：mDs为1：1，搅拌速度900r／min时制备出的微胶囊形态圆整，粒径范围6～24gm，药物包封率达25．12％，在人工肠液中可平稳缓释达8h．

Preparation and Characterization of Diclofenac Sodium Microcapsules

The Diclofenac Sodium microcapsules were prepared by emulsion-solvent diffusion technique using ethyl cellulose as cartier polymer. The technology was optimized by investigating encapsulation efficiency and drug loading. The physicochemical properties of microcapsules such as the appearance and in vitro drug release were characterized. The results show that the prepared microcapsules are spherical with a size distribution range of 6 - 24 μ m under 3×10^-2g/mL of ethyl cellulose in organic solvent,3× 10^-3g/mL of SDS in water, 1.0 of the ratio of Diclofenac Sodium to ethyl cellulose （mEC： mDS） and 900 r/min of stiring rate. The encapsulation efficiency is found to be 25.12 %. Diclofenac Sodium microcapsules can stably release within 8 h in artificial intestinal fluid.