灰树花菌丝体多糖的硫酸酯化及其降血脂作用

对灰树花茵丝体的水不溶性多糖进行硫酸酯化，得到硫酸酯化多糖（S-GF），并对其进行降血脂活性研究．通过对S-GF的红外光谱分析，其中两个特征吸收峰（1236和823cm^-1）的出现表明硫酸酯化反应已经完成．S-GF中硫酸根质量分数为17．7％．通过Sephadex G50柱层析图谱，证明S-GF为均一组分．小鼠实验表明，S—GF明显反映出对小鼠血脂的调节作用．在实验条件下给药剂量为50mg／（kg·d）时，高血脂症模型小鼠可达到治愈的程度．S-GF呈现出明显的降血脂作用．

Sulfation and Hypolipidemic Effect of Polysaccharide of Grifola frondosa Mycelia

Determine hypolipidemic effects of a chemically sulfated polysaccharide （S-GF） ,which was derived from water- insoluble polysaccharide of Grifolafrondosa mycelia. Two characteristic absorption bands （1 236 and 823 cm^-1） appeared in FTIR spectrum of S-GF,which indicated that the sulfation reaction had actually occurred. The sulfur content in S-GF was 17.7%. A single and homogeneous peak was found on Sephadex G50 chromatographic profile for S-GF. S-GF showed the notable regulating effect on mice blood lipidemic profile. Hyperlipidemia models were cured at the dose of 50 mg/（kg·d）. S-GF indicated notable hypolipidemic effects.