| 达英-35联合二甲双胍治疗克罗米芬不敏感型PCOS不孕的临床观察 |
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| 引用本文： | 周建萍,柒铭铭.达英-35联合二甲双胍治疗克罗米芬不敏感型PCOS不孕的临床观察[J].南华大学学报(医学版),2008,36(4):485-487. |
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| 作者姓名： | 周建萍 柒铭铭 |
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| 作者单位： | 株洲市一医院妇产科,湖南,株洲,412000 |
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| 摘 要： | 目的评估达英-35联合二甲双胍对克罗米芬（cc）不敏感型多囊卵巢综合征（PCOS）不孕患者的治疗作用。方法64例CC不敏感型PCOS患者随机分成二甲双胍组、达英-35组和联合用药组，治疗后CC促排卵；比较各项观察指标的变化。结果联合用药组相对于二甲双胍组和达英-35组，体质指数（BMI）、雄激素（T）、黄体生成素（LH）、LH／FSH、空腹胰岛素（Ins）、平均卵泡数下降（P〈0．05），排卵率和妊娠率明显增高（P〈0．05）。结论达英-35联合二甲双胍能有效纠正高雄激素血症，同时改善胰岛素抵抗．增加青．罗米芬治疗后排卵卒和妊娠率。
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| 关 键 词： | 多囊卵巢综合征 达英-35 二甲双胍 克罗米芬 |
Clinical Observation of Cyproterone Acetate Associated with Metformin in Patients with PCOS Unsensitive to CC |
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| ZHOU Jian-ping,QI Ming-ming.Clinical Observation of Cyproterone Acetate Associated with Metformin in Patients with PCOS Unsensitive to CC[J].Journal of Nanhua University(Medical Edition),2008,36(4):485-487. |
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| Authors: | ZHOU Jian-ping QI Ming-ming |
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| Affiliation: | ZHOU Jian-ping,QI Ming-ming (Gynecology , Obstricts Department,the First Hospital of Zhuzhou City,Zhuzhou,Hunan 412000,China) |
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| Abstract: | Objective To evaluate the effects of cyproterone acetate associated with metformin in patients with polycystic ovary syndrome(PCOS) unsensitive to CC. Methods 64 patients were divided to 3 groups in random: metformin group,cyproterone acetate group,metformin associated with cyproterone acetate group.We induced ovulation with CC to observe the changes of different index after therapy. Results In metformin associated with cyproterone acetate group,BMI,androgen,LH,LH/FSH,Ins,the average number of follicle decr... |
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| Keywords: | PCOS cyproterone acetate metformin CC |
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