| 组织型纤溶酶原激活剂(t-PA)及其突变体的表达研究进展 |
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| 引用本文： | 江洁,路福平,杜连祥.组织型纤溶酶原激活剂(t-PA)及其突变体的表达研究进展[J].药物生物技术,2003,10(4):251-255. |
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| 作者姓名： | 江洁 路福平 杜连祥 |
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| 作者单位： | 1. 天津科技大学,天津,300222;齐齐哈尔大学,黑龙江,齐齐哈尔,161006
2. 天津科技大学,天津,300222 |
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| 摘 要： | 对组织型纤溶酶原激活剂(t-PA)及其突变体在大肠杆菌、酵母、哺乳动物细胞、丝状真菌、昆虫细胞和转基因动物乳腺等表达系统中进行表达的研究工作情况进行了综述，并对各个表达系统的优缺点进行了比较。
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| 关 键 词： | 组织型纤溶酶原激活剂 突变体 表达系统 基因工程药物 t-PA |
| 文章编号： | 1005-8915(2003)04-0251-05 |
Progresses in the Expression of Tissue-Type Plasminogen Activator and Its Mutants |
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| GANG Jie ,LU Fu-ping ,DU Lian-xiang.Progresses in the Expression of Tissue-Type Plasminogen Activator and Its Mutants[J].Pharmaceutical Biotechnology,2003,10(4):251-255. |
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| Authors: | GANG Jie LU Fu-ping DU Lian-xiang |
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| Affiliation: | GANG Jie 1,2,LU Fu-ping 1,DU Lian-xiang 1 * |
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| Abstract: | The article concluded the progresses in the expression of tissue-type plasminogen activator and its mutants. Tissue-type plasminogen activator and its mutants have been cloned and expressed effectively in many biological cells,such as Escherichia coli.,yeast,insect cells,filamentous fungus, mammalian animal cells and transgenic mice mammary gland.The advantage and weakness of these expression systems were also compared. |
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| Keywords: | Tissue-type plasminogen activator Mutant Expression system |
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