| 人慢性放射性皮肤溃疡中端粒酶活性升高 |
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| 引用本文： | 李晓瑛,赵坡,王德文,杨志祥.人慢性放射性皮肤溃疡中端粒酶活性升高[J].中华放射医学与防护杂志,1997,17(6):408-409. |
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| 作者姓名： | 李晓瑛 赵坡 王德文 杨志祥 |
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| 作者单位： | 北京放射医学研究所病理学研究室 |
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| 摘 要： | 探讨人慢性放射性皮肤溃疡中端粒酶活性状况及其与癌变的可能关系。方法应用非同位素端粒重复序列扩增技术检测２０例人慢性放射性皮肤溃疡，５例正常皮肤，５例癌组织。结果放射性皮肤溃疡端粒酶活性升高阳性率为３０．０％（６／２０）；正常皮肤组织为阴性（０／５）；癌组织阳性率为１００％（５／５），放射性皮肤溃疡的端粒酶活性强度稍弱于癌组织。结论端粒酶活性测定可能成为判定慢性放射性皮肤溃疡预后和治疗效应的标志
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| 关 键 词： | 放射性皮肤溃疡 端粒酶 癌 |
| 收稿时间： | 1996/9/23 0:00:00 |
| 修稿时间： | 1996/12/16 0:00:00 |
Elevation of telomerase activity in chronic radiation ulcer of human skin |
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| Li Xiaoying,Zhao Po,Wang Dewen and Yang Zhixiang.Elevation of telomerase activity in chronic radiation ulcer of human skin[J].Chinese Journal of Radiological Medicine and Protection,1997,17(6):408-409. |
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| Authors: | Li Xiaoying Zhao Po Wang Dewen and Yang Zhixiang |
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| Affiliation: | Li Xiaoying,Zhao Po,Wang Dewen and Yang Zhixiang.Department of Pathology,Institute of Radiation Medicine,Beijing 100850 |
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| Abstract: | bjective\ To investigate the levels of telomerase activity in chronic radiation ulcers of human skin and the possible relationship between the enzyme and cancer transformation.Method\ Using nonisotopic telomere repeat amplification protocol (TRAP),detections were performed in 20 cases of chronic radiation ulcers of human skin,5 cases of normal skin tissues and 5 cases of carcinoma.Results\ The positive rates for telomerase activity were 30.0% (6/20),0(0/5) and 100%(5/5) in chronic radiation ulcers of human skin,normal skin and carcinoma,respectively.The telomerase activity in radiation ulcer was weaker than in carcinoma.Conclusion\ The telomerase activity assay might be used as a marker for predicting the prognosis and the effect of treatment in chronic radiation ulcer of human skin. |
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| Keywords: | Radiation skin ulcer Telomerase Cancer |
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