| 阿托品对兔局部脑缺血Ca2+积累和细胞水肿的作用 |
| |
| 引用本文： | 吕爱刚,胡香杰,贾丹辉,张贵卿,可 君.阿托品对兔局部脑缺血Ca2+积累和细胞水肿的作用[J].中国药理学与毒理学杂志,1998,12(3):237-238. |
| |
| 作者姓名： | 吕爱刚 胡香杰 贾丹辉 张贵卿 可 君 |
| |
| 作者单位： | 河南医科大学药理学教研室 |
| |
| 摘 要： | 阿托品对兔局部脑缺血Ｃａ２＋积累和细胞水肿的作用吕爱刚胡香杰贾丹辉张贵卿可君（河南医科大学药理学教研室，郑州４５００５２）阿托品（ａｔｒｏｐｉｎｅ，Ａｔｒ）为一典型的Ｍ受体阻断剂，近年研究表明它可以选择性对抗ＫＣｌ和ＣａＣｌ２对兔基底动脉收缩作用，其...
|
| 关 键 词： | 脑缺血 阿托品 钙 钠 钾 脑水肿 |
| 收稿时间： | 1997-2-28 |
Effect of atropine on Ca2+ accumulation and cell edema induced by regional ischemia in rabbit brains |
| |
| LU Ai-Gang, HU Xiang-Jie, JIA Dan-Hui, ZHANG Gui-Qing, KE Jun.Effect of atropine on Ca2+ accumulation and cell edema induced by regional ischemia in rabbit brains[J].Chinese Journal of Pharmacology and Toxicology,1998,12(3):237-238. |
| |
| Authors: | LU Ai-Gang HU Xiang-Jie JIA Dan-Hui ZHANG Gui-Qing KE Jun |
| |
| Affiliation: | (Department of Pharmacology, Henan Medical University, Zhengzhou 450052) |
| |
| Abstract: | Experimental brain ischemia model was prepared by middle cerebral artery occlusion(MCAO) operation in rabbits. Effects of atropine(Atr) on Ca2+, Na+, K+, H2O contents of ischemic area were examined 5 h after MCAO. Atr 0.7 mg·kg-1·h-1, iv, 5 min after MCAO for 5 h significantly reduced Ca2+ accumulation, Na+ level and H2O content in ischemic area (P<0.01). Atr 0.35 mg·kg-1·h-1 iv for 5 h after MCAO also reduced Na+ contents in ischemic area (P<0.05). The results suggest that Atr protect regional brain ischemia infarct and edema in rabbits. |
| |
| Keywords: | cerebral ischemia atropine calcium sodium potassium brain edema |
| 本文献已被 CNKI 维普 等数据库收录！ |
| 点击此处可从《中国药理学与毒理学杂志》浏览原始摘要信息 |
|
点击此处可从《中国药理学与毒理学杂志》下载全文 |
|
