Total synthesis of malayamycin A and analogues |
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| Authors: | Stephen Hanessian Stéphane Marcotte Guobin Huang Olivier Loiseleur |
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| Affiliation: | a Department of Chemistry, Université de Montréal, CP 6128, Station Centre-Ville, Montréal, QC H3C 3J7, Canada
b Syngenta Crop Protection AG, Switzerland |
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| Abstract: | The total synthesis of the bicyclic C-nucleoside malayamycin A is described starting with d-ribonolactone. A new method was developed to obtain preparatively important quantities of β-pseudouridine, which was used as an intermediate. The synthesis of a carba N-nucleoside analogue of malayamycin A is also described. |
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| Keywords: | C-Nucleoside Thioglycoside Ring closure metathesis Perhydrofuropyran |
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