| 肝移植患者术中氧自由基相关指标的变化 |
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| 引用本文： | 刘淳,周孝思,耿秋明.肝移植患者术中氧自由基相关指标的变化[J].天津医药,2004,32(10):616-618. |
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| 作者姓名： | 刘淳 周孝思 耿秋明 |
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| 作者单位： | 100083,北京大学第三医院 |
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| 摘 要： | 目的：研究在肝移植术中氧自由基对肝脏缺血再灌注损伤的作用。方法：测定比较18例肝移植患者术前、无肝期、再灌注后1h血浆中脂质过氧化物(LPO)、超氧化物歧化酶(SOD)、总抗氧化能力(TAC)、一氧化氮水平(NO)，分析其变化。结果：再灌注后LPO和TAC下降，SOD和NO升高。结论：氧自由基在肝移植缺血再灌注损伤中有重要作用，再灌注后，激活了保护机制，手术中输血及某些药物的使用也可以减轻自由基损害，对机体具有保护作用。
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| 关 键 词： | 肝移植 氧自由基 再灌注 术中 患者 相关指标 LPO 结论 变化 重要作用 |
The Alteration of Oxygen Free Radicals Relate Index During Liver Transplantation |
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| LIU Chun,ZHOU Xiaosi,GENG Qiuming The Third Hospital of Beijing University,Beijing,China.The Alteration of Oxygen Free Radicals Relate Index During Liver Transplantation[J].Tianjin Medical Journal,2004,32(10):616-618. |
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| Authors: | LIU Chun ZHOU Xiaosi GENG Qiuming The Third Hospital of Beijing University Beijing China |
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| Affiliation: | LIU Chun,ZHOU Xiaosi,GENG Qiuming The Third Hospital of Beijing University,Beijing100083,China |
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| Abstract: | Objective:To study the effect of oxygen free radicals on hepatic ischemia-reperfusion injury during liver transplantation.Methods:Plasma LPO,SOD,TAC and NO of18patients were measured preop-eratively,an hepatic phase and1hour after reperfusion.Results:The plasma LPO and TAC declined,SOD and NO elevated after reperfusion.Conclusion:Oxygen free radicals play an important role in hepatic ischemia-reperfusion injury during liver transplantation.After reperfusion,protective mechanism was activated.Blood transfusion and some drug may alleviate the injury caused by free radicals and protect body. |
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| Keywords: | reactive oxygen species lipid peroxidation liver transplantation reperfusion injury |
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