| 呼吸道合胞病毒融合蛋白变异及其对抗体和药物效果的影响 |
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| 引用本文： | 郝焕,聂建辉,王玉琳,黄维金,王佑春.呼吸道合胞病毒融合蛋白变异及其对抗体和药物效果的影响[J].中国病毒病杂志,2021(1):63-69. |
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| 作者姓名： | 郝焕 聂建辉 王玉琳 黄维金 王佑春 |
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| 作者单位： | 国药中生生物技术研究院有限公司;中国食品药品检定研究院国家卫生健康委员会生物技术产品检定方法与标准化重点实验室国家药品监督管理局生物制品质量研究与评价重点实验室 |
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| 基金项目： | 国家“十三五”艾滋病和病毒性肝炎等重大传染病防治科技重大专项(2018ZX10731101-002-006,2018ZX10731101-002-009,2018ZX10731101-001-006);国家重大新药创制科技重大专项(2018ZX09101001)。 |
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| 摘 要： | 呼吸道合胞病毒(respiratory syncytial virus,RSV)是造成婴幼儿与老年人下呼吸道感染和住院的主要原因之一.目前开发疫苗、抗体及药物成为防控RSV的热点,其主要靶点是融合蛋白(fusion glyco-protein,F).本文分析了现有RSV病毒株融合蛋白的变异情况,剖析了融合蛋白的结构特点...
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| 关 键 词： | 呼吸道合胞病毒 融合蛋白 中和表位 变异株 |
Variation of respiratory syncytial virus F protein and its effect on antibodies and drugs: recent progress |
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| HAO Huan,NIE Jian-hui,WANG Yu-lin,HUANG Wei-jin,WANG You-chun.Variation of respiratory syncytial virus F protein and its effect on antibodies and drugs: recent progress[J].Chinese Journal of Viral Diseases,2021(1):63-69. |
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| Authors: | HAO Huan NIE Jian-hui WANG Yu-lin HUANG Wei-jin WANG You-chun |
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| Affiliation: | (National Vaccine&Serum Institute,Beijing 101111,China;National Institutes for Food and Drug Control,Key Laboratory of National Health Commission for Research on Quality and Standardization of Biotech Products,Key Laboratory of Biological Product Quality Research and Evaluation of National Medical Products Administration,Beijing 102629,China;不详) |
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| Abstract: | Respiratory syncytial virus(RSV) is one of the main causes of lower respiratory tract infections and hospitalization among infants and the elders.Development of vaccine, monoclonal antibodies and chemical drugs are becoming hot topics for the prevention and treatment of RSV.Most of these products are based on RSV fusion glycoprotein(F) protein.In this review, the variation of F protein in existing RSV strains and the structure characteristics were summarized.The binding sites and escapes of some monoclonal antibodies and chemical drugs against F protein were reviewed.This will help to develop broad and efficient RSV vaccines and drugs. |
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| Keywords: | Respiratory syncytial virus Fusion glycoprotein Neutralization epitope Variant |
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