氯丙嗪对精神分裂症患者外周血T细胞亚群的影响

本文应用抗人Ｔ淋巴细胞单克隆抗体ＯＫＴ系列从间接免疫荧光法检测５４例精神分裂症患者外周血Ｔ淋巴细胞亚群，以探讨氯丙嗪对其影响。结果发现精神分裂症患者Ｔ淋巴细胞亚群间的紊乱出现于服用氯丙嗪等药物之前，从未服用药物的新发病患者与已服氯丙嗪等药一月以上的患者均存在免疫功能异常，服药组与未服药组之间无明显差异，提示精神分裂症患者细胞免疫功能异常与氯丙嗪等抗精神病药物无明显关系。

EFFECT OF CHLORPRO-MAZINE ON PERIPHERALBLOOD T CELL SUBPOPULA-TION OF SCHIZOPHRENIC PA-TIENT

e ued indirect immunofluorescence with antihunan TLmonoclonoal antibody OKT series to detect peripheral blood Tcall subpopulation of 54 schizophrenir petients in order lo inves-tigate chlor promazine's effect to them. The results found thedisturbance in TL subpopulation of schizophrenic petients ac-cured befote petients took chlorpromazine, new patients whonever took medicine and those who had taken chlorpromazinefor more than one month both had abnormal immunologic func-tion ,There was no significart difference between the medicationgroup and the non-medication group. It showed that the abnor-mal cell immunologic function of schizophrenic petients did nothave obvious relation with chlorpromazine and other anti-psy-chotic medicine.