四种激素制剂用于绝经期激素补充治疗的比较

目的 :比较 4种用于激素补充治疗的制剂的疗效和副作用 ,为选择用药提供参考。方法 :96例绝经妇女随机分为 4组 ,各服用克龄蒙、尼尔雌醇、妇复春和妇舒宁 6个月。用药前、后观察绝经期症状 ,检测血总胆固醇 (CHOL)、甘油三酯 (TG)、高密度脂蛋白 (HDL)和低密度脂蛋白(LDL)、骨密度及子宫内膜厚度。结果 :用药后 4组之绝经期症状均明显改善 ,Kupperman评分显著下降 ;除尼尔雌醇组TG下降及妇复春组HDL上升无统计学意义外 (P >0 0 5 ) ,其余各组CHOL、TG及LDL均明显下降 ,HDL明显上升 (P <0 0 5或 0 0 1) ;4组之骨密度均无明显变化 (P >0 0 5 ) ;无 1例宫内膜过度增生。对上述指标之影响 ,4种制剂间相比较无显著性差异 (P >0 0 5 )。结论 :4种制剂均能显著改善绝经期症状 ,有利血脂代谢和抑制骨丢失

Comparative study with four agents hormone replacement therapy in postmenopausal women

Aim: To compare the effect of four agents hormone replacement therapy in postmenopausal four agents hormone replacement therapy in postmenopausal women for choosing agent. Methods: 96 cases were divided into four groups randomly, Climen group,Nilestriol (CEE 3) group,Fufuchun group and Oesclim group,hormone replacement therapy for 6 months. Climacteric symptoms,four lipoproteins cholesterin (CHOL), triglycerin (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), bone mineral density (BMD) and the thicknes of endometrium were evaluated before and 6 months after treatment. Results: After 6 months, Kupperman score decreased significantly all groups (P<0.01),except CEE 3 group TG decreased and Fufuchun group HDL increased no significance statisticlly (P>0.05),CHOL?TG?LDL decreased and HDL increased significantly all groups (P<0.05 or <0.01). BMD no changed significantly four groups all (P>0.05). None endometrial hyperplasia . The above changes are not obvious significance statisticlly between four groups (P>0.05). Conclusion: Four agents can improve significantly in climacteric symptoms,are beneficial to lipoproteins metabolism and restrain bone loss in postmenopausal women.