香烟烟雾吸入对大鼠局灶性脑缺血后梗死灶的影响

目的 观察香烟烟雾吸入对大鼠局灶性脑缺血后梗死灶的影响，探讨其机制。方法 建立吸烟大鼠模型。用TTC染色法测定梗死灶体积，检测大鼠局灶性脑缺血后神经功能缺陷评分及梗死灶体积占同侧半球百分比。结果 除戒烟组外各吸烟组大鼠神经功能缺陷评分及梗死灶体积与对照组相比显著增加，吸烟4周、8周及12周依次增加。戒烟组神经功能评分及梗死体积明显低于吸烟4周组，与对照组无显著差别。结论 吸烟可加重大鼠局灶性脑缺血后脑组织损害，且随着吸烟时间增加而加重，戒烟可使这种脑损害得到一定程度的恢复。

Effect of cigarette smoking on infarct focus after focal cerebral ischemia in rats

Objective: To observe the effect of cigarette smoking on infarct focus after focal cerebral ischemia in rats, discuss the mechanism. Methods: Animal model of smoking was made and TTC staining method was used to detect infarct volume. The neurological function score and infarct volume ratio after focal cerebral ischemia in rats were detected. Results: Compared with the control group, the neurological function score and infarct volume ratio in smoking group except stop smoking group were significantly increased. Smoking-4 week, 8 week, and 12 week group were increased successively. Stop smoking group were significantly reduced compared with the smoking-4 week group and there were no significant difference between the stop smoking group and control group. Conclusions: Cigarette smoking can aggravate brain cerebral damage after focal cerebral ischemia in rats and the damage was aggravarting with smoking time increasing. Stop smoking can make cerebral damage recover to some extent.