| 下呼吸道感染常见病原菌分布及其耐药性分析 |
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| 引用本文： | 陈国军,胡忠杰,陆建红,苗佩宏.下呼吸道感染常见病原菌分布及其耐药性分析[J].中华医院感染学杂志,2010,20(4). |
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| 作者姓名： | 陈国军 胡忠杰 陆建红 苗佩宏 |
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| 作者单位： | 1. 武警浙江省总队医院检验科,浙江,嘉兴,314000
2. 武警浙江省总队医院药械科,浙江,嘉兴,314000 |
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| 摘 要： | 目的 探讨住院患者下呼吸道感染病原菌的临床分布特点及耐药状况,为临床合理使用抗菌药物提供参考.方法 对2005～2008年住院患者下呼吸道感染痰标本所分离的病原菌,进行菌种和耐药情况回顾性统计分析.结果 4年来医院下呼吸道感染的病例中共分离出4154株病原菌,其中革兰阴性菌2650株,占63.8%;革兰阳性菌980株,占23.6%;真菌524株,占12.6%;下呼吸道感染病原菌前几位依次为铜绿假单胞菌、鲍氏不动杆菌、大肠埃希菌、肺炎克雷伯菌和金黄色葡萄球菌等;铜绿假单胞菌和鲍氏不动杆菌呈多药耐药且对亚胺培南耐药率上升明显;除亚胺培南外,肠杆菌科细菌对其他抗菌药物的耐药率呈逐年上升趋势;产ESBLs菌株的耐药率明显高于非产ESBLs菌株;金黄色葡萄球菌中耐甲氧西林金黄色葡萄球菌(MRSA)的分离率较高.结论 下呼吸道感染病原菌以革兰阴性杆菌为主,主要的病原菌对临床常用抗菌药物耐药呈上升趋势,临床应加强病原菌耐药的监测,合理应用抗菌药物,以延缓病原菌耐药性的产生.
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| 关 键 词： | 下呼吸道感染 病原菌 耐药性 |
Distribution and Antibiotic Resistance of Pathogens Isolated from Nosocomial Lower Respiratory Tract Infection |
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| CHEN Guo-jun,HU Zhong-jie,LU Jian-hong,MIAO Pei-hong.Distribution and Antibiotic Resistance of Pathogens Isolated from Nosocomial Lower Respiratory Tract Infection[J].Chinese Journal of Nosocomiology,2010,20(4). |
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| Authors: | CHEN Guo-jun HU Zhong-jie LU Jian-hong MIAO Pei-hong |
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| Abstract: | OBJECTIVE To investigate the distribution and antibiotic resistance of pathogens isolated from nosocomial lower respiratory tract infections to offer rational antimicrobial therapy.METHODS A retrospective analysis for the antibiotic resistance of pathogens isolated from sputum samples of nosocomial lower respiratory tract infections were made in our hospital from 2005 to 2008.RESULTS Totally 4154 pathogenic strains,including 2650 strains of Gram-negative bacteria(63.8%),980 strains of Gram-positive bacteria... |
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| Keywords: | Lower respiratory tract infection Pathogen Antibiotic resistance |
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