Human cytomegalovirus UL76 induces chromosome aberrations |
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| Authors: | Voon-Kwan Siew Chang-Yih Duh Shang-Kwei Wang |
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| Affiliation: | (1) Department of Microbiology, Institute of Medicine, College of Medicine, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, 80708 Kaohsiung, Taiwan;(2) Asia-Pacific Ocean Research Center, National Sun Yat-sen University, 70 Lien-Hai Road, 80424 Kaohsiung, Taiwan |
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| Abstract: | Background Human cytomegalovirus (HCMV) is known to induce chromosome aberrations in infected cells, which can lead to congenital abnormalities
in infected fetuses. HCMV UL76 belongs to a conserved protein family from herpesviruses. Some reported roles among UL76 family
members include involvement in virulence determination, lytic replication, reactivation of latent virus, modulation of gene
expression, induction of apoptosis, and perturbation of cell cycle progression, as well as potential nuclease activity. Previously,
we have shown that stable expression of UL76 inhibits HCMV replication in glioblastoma cells. |
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