| 巯甲丙脯酸对实验性高血压大鼠心肌缺血-再灌注损伤的保护作用 |
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| 引用本文： | 张连元,张之玮,董淑云,金光灿,郑素琴;唐朝枢,苏静怡.巯甲丙脯酸对实验性高血压大鼠心肌缺血-再灌注损伤的保护作用[J].中国现代应用药学,1996(3):5-7. |
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| 作者姓名： | 张连元 张之玮 董淑云 金光灿 郑素琴;唐朝枢 苏静怡 |
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| 作者单位： | 华北煤炭医学院病理生理教研室(张连元，张之玮，董淑云，金光灿，郑素琴)，北京医科大学心血管基础研究所(唐朝枢，苏静怡) |
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| 摘 要： | 为探讨巯甲丙脯酸（ｃａｎｔｏｐｒｉｌ）对高血压肥大心肌缺血－丙灌注的影响，本实验以造成大鼠腹主动脉狭窄的方法复制高血压模型，观察了应用巯甲丙脯酸的高血压大鼠肉体心脏缺血－再灌注的变化。结果显示未用药的高血压大鼠，离体心脏在缺血－再灌注后出现心肌细胞乳酸脱氢酶的漏出和丙二醛生成增加及组织钙含量增加等损伤性变化，而预先应用巯甲丙脯酸处理的高血压大鼠，乳酸脱氢酶和丙二醛增高的情况明显减轻，避免了钙在心肌内过多积聚。表明巯甲丙脯酸具有抗高血压肥大心肌缺血－再灌注损伤的作用。
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| 关 键 词： | 巯甲丙，脯酸，缺血－再灌注损伤，高血压 |
Protective Action of Capotpril on Myocardial Ischemia-reperfusion Injury in Hypertensive Rats |
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| Zhang Lian-yuan et al.Protective Action of Capotpril on Myocardial Ischemia-reperfusion Injury in Hypertensive Rats[J].The Chinese Journal of Modern Applied Pharmacy,1996(3):5-7. |
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| Authors: | Zhang Lian-yuan |
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| Abstract: | In order to investigate the effect of captopril on hypertension myocardial ischemia-reperfusion , the changes of hypertrophic myocardia in hypertension model rats were observed.Results showed that, after inchemia -reperfusion, the lactate dehydrogenase escaped from cytopl-asma, the production of malondialdehyde and calcium content increased , while being pretreated with captopril these changes were alleviated. These results indicated that captopril can protect hypertension heart against ischemia-reperfusion injury. |
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| Keywords: | : captopril hypertension ischemia-reperfusion injury |
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