| 柿叶乙醇提取物治疗大鼠高脂血症的实验研究 |
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| 引用本文： | 邓瑞春,张文生,杨洪军,孟繁蕴,杜树山,华晔,孙丽平,王永炎.柿叶乙醇提取物治疗大鼠高脂血症的实验研究[J].中国中医药信息杂志,2004,11(6):493-494. |
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| 作者姓名： | 邓瑞春 张文生 杨洪军 孟繁蕴 杜树山 华晔 孙丽平 王永炎 |
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| 作者单位： | 1. 北京师范大学资源学院资源药物与中药资源研究所,北京,100875
2. 中国中医研究院,北京,100700 |
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| 摘 要： | 目的 研究柿叶乙醇提取物对大鼠高脂血症的治疗作用。方法 采用食饵性高脂血大鼠模型，以康利脂为阳性对照药，观察柿叶乙醇提取物对血脂的影响。结果 柿叶乙醇提取物能显著降低高脂血症大鼠血清胆固醇(TC)、三酰甘油(TG)和低密度脂蛋白(LDL-C)，并能显著升高高密度脂蛋白(HDL-C)在血清中的含量。与阳性药康利脂相比较，柿叶乙醇提取物给药1周后的作用较低，给药2周后的作用与康利脂的作用相当，且未见毒副作用。结论 柿叶乙醇提取物对大鼠高脂血症有显著的治疗作用。
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| 关 键 词： | 柿叶 高脂血症 大鼠 |
| 文章编号： | 1005-5304(2004)06-0493-02 |
| 修稿时间： | 2004年4月15日 |
Effect of Leaf of Persimmon Oral Solution on Serum Lipid Levels of Rats with Experimental Hyperlipemia |
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| DENG Rui-chun,ZHANG Wen-sheng,YANG Hong-jun,et al.Effect of Leaf of Persimmon Oral Solution on Serum Lipid Levels of Rats with Experimental Hyperlipemia[J].Chinese Journal of Information on Traditional Chinese Medicine,2004,11(6):493-494. |
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| Authors: | DENG Rui-chun ZHANG Wen-sheng YANG Hong-jun |
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| Affiliation: | DENG Rui-chun1,ZHANG Wen-sheng1,YANG Hong-jun2,et al |
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| Abstract: | Objective To investigate effect of leaf of persimmon oral solution on serum lipid levels of rats with experimental hyperlipemia. Methods Rats were fed on high fat forage for 2 weeks to make the model of hyperlipemia, two of the model groups were orally given leaf of persimmon oral solution in doses of 25 and 100 mg/kg of body weight respectively. Serum levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were assayed before and after 1 and 2 weeks of administration. Results Levels of serum TG, TG, LDL-C were lowered and HDL-C were increased in the two dosage groups. Conclusion Leaf of persimmon oral solution could lower serum lipid in rats with hyperlipemia. |
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| Keywords: | leaf of persimmon hyperlipemia rats |
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