含氟达拉滨方案治疗CLL/SLL发生输血相关移植物抗宿主病2例并文献复习

目的 探讨输血相关移植物抗宿主病(TA-GVHD)的临床表现、诊断标准,与氟达拉滨治疗的相关性及预防措施.方法 回顾总结2例接受氟达拉滨化疗的慢性淋巴细胞白血病(CLL)/小淋巴细胞淋巴瘤(SLL)患者的临床资料,化疗后出现TA-GVHD的临床表现、治疗及转归,并复习相关文献.结果 2例患者化疗前后间断多次输血,均出现...

Transfusion-associated GVHD after fludarabine therapy in patients with CLL/SLL: Report of two cases and re view of the literatures

Objective To investigate the manifestations,diagnosis,preventive measure of transfusion-associated graft-versus-host disease（TA-GVHD）,and the relationship between TA-GVHD and fludarabine.Methods Clinical data of two chronic lymphatic leukemia（CLL）/ small lymphocytic lymphoma（SLL）patients including the manifestations,treatment and prognosis were investigated.The relevant literatures were reviewed.Results Both patients appeared high fever,extensive congestive macula,inconvertible pancytopenia,hepatic lesion after transfusion,and still aggravated after glucocorticosteroid therapy,and gave up therapy because of severe complication,including oral mucosa inflammation,pulmonary infection and respiratory failure.Conclusion Patients treated with fludarabine appear to be at risk for TA-GVHD because their lymphatic system and immune function will be restrainted for a long time,and easily develop GVHD after transfusion with blood products containing active lymphocytes.TA-GVHD will aggravate quickly and result in multiple organ failure or sever infection and haemorrhage.Irradiating blood products before transfusion will be an effective measure to prevent TA-GVHD.