| T淋巴细胞亚群水平对阿德福韦酯治疗慢性乙型肝炎疗效的影响 |
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| 引用本文： | 蒋阳昆,涂燕云,许剑,陈黎,林海.T淋巴细胞亚群水平对阿德福韦酯治疗慢性乙型肝炎疗效的影响[J].实用肝脏病杂志,2010,13(4):263-264. |
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| 作者姓名： | 蒋阳昆 涂燕云 许剑 陈黎 林海 |
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| 作者单位： | 1. 广西中医学院附属瑞康医院肝胆内科,南宁市,530011
2. 贵阳中医学院第二附属医院消化内科 |
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| 基金项目： | 广西中医学院自然科学基金资助项目 |
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| 摘 要： | 目的观察T淋巴细胞亚群变化对阿德福韦酯治疗CHB患者疗效的影响。方法根据治疗前T淋巴细胞亚群水平将42例CHB患者分为CD4+/CD8+细胞比值低水平组和高水平组,观察阿德福韦酯治疗12个月的疗效。结果治疗后两组患者ALT和AST水平下降,但高水平组下降更明显(P0.05);治疗后两组患者血清HBVDNA水平分别为4.2±1.2copies/ml和4.5±1.5copies/m(lP0.05);治疗后高水平组患者HBeAg阴转率为38.89%(7/18),低水平组为18.75%(3/16,P0.05)。结论治疗前T淋巴细胞亚群水平较高的CHB患者在应用阿德福韦酯治疗后疗效较好。
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| 关 键 词： | 慢性乙型肝炎 T淋巴细胞亚群 阿德福韦酯 疗效 |
T-lymphocyte subsets levels on the efficacy of adefovir in the treatment of patients with chronic hepatitis B |
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| Affiliation: | JIANG Yangkun,TU Yanyun,XU Jian,et al. (Ruikang Hospital,Affiliated to Guangxi TCM University, Nanning 530011,Guangxi,China ) |
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| Abstract: | Objective To observe the efficacy of adefovir on patient with CHB. Method 42 CHB patients were divided into two groups based on the ratio of CD4^＋/CD8^＋. Two groups received adefovir for 12 months. Results After 12 months treatment,the high level group got a better improvement in the liver function,HBV DNA loss and HbeAg negative rate. Conclusion Pre-treatment levels of T lymphocyte subgroup in CHB will influence the efficacy of adefovir dipivoxil treatment. |
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| Keywords: | Chronic hepatitis B T lymphocyte subset Adefovir Afficacy |
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