| 山茶花总黄酮TFC对实验性心肌缺血的保护作用 |
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| 引用本文： | 袁丽萍,范丽,董六一,方明,赵维中,陈志武.山茶花总黄酮TFC对实验性心肌缺血的保护作用[J].中药新药与临床药理,2004,15(1):25-28. |
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| 作者姓名： | 袁丽萍 范丽 董六一 方明 赵维中 陈志武 |
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| 作者单位： | 安徽医科大学药理学教研室,合肥,230032 |
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| 摘 要： | 目的观察山茶花总黄酮(TFC)对心肌缺血损伤的保护作用,并初步探讨其作用机制.方法采用挟闭气管造成小鼠心肌缺氧模型和舌下静脉注射垂体后叶素(Pit)制备大鼠心肌缺血模型.结果TFC80,40mg/kg显著延长挟闭气管后小鼠心电消失的时间;60,30mg/kg对iv Pit引起的大鼠ST段和T波的异常心电图变化有明显的抑制作用,并且能显著减少心肌组织及血清中丙二醛(MDA)含量,抑制血清中乳酸脱氢酶(LDH)活力的升高.结论TFC对心肌缺血有明显的保护作用,其机制可能与抗脂质过氧化有关.
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| 关 键 词： | 山茶花总黄酮 心肌缺血 心电图 丙二醛 乳酸脱氢酶 |
| 文章编号： | 1003-9783(2004)01-0025-03 |
| 修稿时间： | 2003年7月19日 |
Protective Effects of Total Flavone C on Myocardial Ischemia in Rats |
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| YUAN Liping,FAN Li,DONG Liuyi,FANG Ming,ZHAO Weizhong,CHEN Zhiwu.Protective Effects of Total Flavone C on Myocardial Ischemia in Rats[J].Traditional Chinese Drug Research & Clinical Pharmacology,2004,15(1):25-28. |
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| Authors: | YUAN Liping FAN Li DONG Liuyi FANG Ming ZHAO Weizhong CHEN Zhiwu |
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| Abstract: | Objective To study the protective effects of total flavone C( TFC) on myocardial ischemia and to explore its mechanism.Methods Two kinds of models were established: mouse model of myocardial ischemia induced by means of clampi ng trachea and rat models of myocardial ischemia induced by pititrin.Results TFC at the concentrations of 80 and 40 mg/kg markedly prolonged the cardioelectric time after clamping the trachea.TFC at the concentrations of 60 and 30 mg/kg can ameliorate the changes of ST and T wave in rat models,reduce the MDA contents in the myocardium and the serum of rats and decrease the activity of LDH in the serum of rats.Conclusion TFC has protective effects on moyocardial ischemia and its mechanism may be related with the inhibition of lipid peroxidation. |
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| Keywords: | Total f lavone C Myocardial ischemia ECG MDA LDH |
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