| 安宫黄体酮母液中两个新化合物的分离与结构鉴定 |
| |
| 引用本文： | 杨中铎,陈华,王友富,林力波,李援朝.安宫黄体酮母液中两个新化合物的分离与结构鉴定[J].药学学报,2005,40(9):830-833. |
| |
| 作者姓名： | 杨中铎 陈华 王友富 林力波 李援朝 |
| |
| 作者单位： | 1. 中国科学院,上海生命科学院,药物研究所,上海,201203
2. 浙江仙居制药二分厂,浙江,317300 |
| |
| 摘 要： | 目的研究药物安宫黄体酮中所含的杂质。方法应用柱色谱方法进行分离和纯化，NMR和MS等波谱方法确定结构。结果从安宫黄体酮母液中分离得到2个化合物。结论化合物1和2为新差向异构体，其结构分别鉴定为：17α-氧乙酰基-2β，6α-二甲基孕甾-4-烯-3，20-二酮；17α-氧乙酰基-2α，6α-二甲基孕甾-4-烯-3，20-二酮。
|
| 关 键 词： | 安宫黄体酮 17α-氧乙酰基-2β，6α-二甲基孕甾-4-烯-3，20-二酮 17α-氧乙酰基-2α，6α-二甲基孕甾-4-烯-3，20-二酮 |
| 文章编号： | 0513-4870（2005）09-0830-04 |
| 收稿时间： | 10 18 2004 12:00AM |
| 修稿时间： | 2004-10-18 |
Isolation and identification of two new epimer from the mother liquid of megestrol acetate |
| |
| YANG Zhong-duo,CHEN Hua,WANG You-fu,LIN Li-bo,LI Yuan-chao.Isolation and identification of two new epimer from the mother liquid of megestrol acetate[J].Acta Pharmaceutica Sinica,2005,40(9):830-833. |
| |
| Authors: | YANG Zhong-duo CHEN Hua WANG You-fu LIN Li-bo LI Yuan-chao |
| |
| Affiliation: | 1. Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China; 2. Zhejiang Xianju Zhiyao Erchang, Zhejiang 317300, China |
| |
| Abstract: | AIM: To study the impurity in the drug megestrol acetate. METHODS: Chromatography methods were used to separate the chemical constituents. Their structures were determined by NMR and MS spectral analysis. RESULTS: Two new epimers were isolated from the mother liquid of the drug megestrol acetate. CONCLUSION: These new epimers were identified as 17alpha-acetoxy-2beta,6alpha-dimethylprega-4-ene-3,20-dione (1) and 17alpha-acetoxy-2alpha,6alpha-dimethylprega-4-ene-3,20-dione (2). |
| |
| Keywords: | 17α-acetoxy-2β 6α-dimethylprega-4-ene-3 20-dione 17α-acetoxy-2α 6α-dimethylprega-4-ene-3 20-dione Megestrol acetate |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《药学学报》浏览原始摘要信息 |
|
点击此处可从《药学学报》下载全文 |
|
