| 蜜环菌的化学成分研究 |
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| 引用本文： | 袁兴利,闫利华,张启伟,王智民.蜜环菌的化学成分研究[J].中国中药杂志,2013,38(16):2671-2674. |
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| 作者姓名： | 袁兴利 闫利华 张启伟 王智民 |
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| 作者单位： | 中国中医科学院 中药研究所, 北京 100700;中药质量控制技术国家工程实验室, 北京 100700;天津中医药大学, 天津 300193;中国中医科学院 中药研究所, 北京 100700;中药质量控制技术国家工程实验室, 北京 100700;中国中医科学院 中药研究所, 北京 100700;中药质量控制技术国家工程实验室, 北京 100700;中国中医科学院 中药研究所, 北京 100700;中药质量控制技术国家工程实验室, 北京 100700 |
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| 基金项目： | 国家"重大新药创制"科技重大专项(2009ZX09308-003,2009ZX09301-005);中国中医科学院自主选题项目(2011xycz-11) |
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| 摘 要： | 对蜜环菌Armillaria mellea发酵培养物的化学成分进行研究。采用硅胶、Sephadex LH-20柱色谱等方法进行分离纯化,根据波谱数据及与对照品对照鉴定化合物结构。从蜜环菌发酵培养物中分离鉴定了10个化合物,分别为2-羟基-4-甲氧基-6-甲基苯甲酸(1),苔藓酸(2),蜜环菌戊素(3),麦角甾醇(4),染料木素(5),大豆素(6),胡萝卜苷(7),染料木苷(8),尿嘧啶(9)和甘露醇(10)。化合物 1~10 均为首次从蜜环菌发酵培养物中分离得到,其中,化合物 1~4,6,10 在蜜环菌菌丝体或菌索中已有报道。通过二维核磁波谱确证,首次报道化合物3以DMSO为溶剂的氢、碳谱数据,是对该类成分波谱数据的补充。
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| 关 键 词： | 蜜环菌 口蘑科 化学成分 |
| 收稿时间： | 4/8/2013 12:00:00 AM |
Chemical constituents from fungus Armillaria mellea |
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| YUAN Xing-li,YAN Li-hu,ZHANG Qi-wei and WANG Zhi-min.Chemical constituents from fungus Armillaria mellea[J].China Journal of Chinese Materia Medica,2013,38(16):2671-2674. |
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| Authors: | YUAN Xing-li YAN Li-hu ZHANG Qi-wei and WANG Zhi-min |
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| Affiliation: | Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines, Beijing 100700, China;Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines, Beijing 100700, China |
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| Abstract: | Ten compounds were isolated from cultures of the fungus Armillaria mellea by silica gel and Sephadex LH-20 column chromatographies. Their structures were identified by spectroscopic data analysis and compared their spectroscopic data with those reported in the literature as 2-hydroxy-4-methoxy-6-methylbenzoic acid(1), orsellinic acid(2), melleolide(3), ergosterol(4), genistein(5), daidzein(6), daucosterol(7), genistin(8), uracil(9) and D-mannitol(10). Compounds 1-10 were isolated from cultures of A. mellea for the first time. Among them, 1-4, 6 and 10 had been obtained from mycelia or rhizomorphs of A. mellea. The structure of compound 3 was determined by detailed analysis of its 1D and 2D NMR data in the solvent of DMSO for the first time. |
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| Keywords: | Armillaria mellea Tricholomataceae chemical constituents |
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