社会心理因素、5-HTTLPR多态性与乳腺癌患者抑郁症状的相关性研究

目的：探讨乳腺癌患者5-羟色胺转运体基因启动子区多态性（5-HTTLPR）、社会心理因素与抑郁症状发生及严重程度的相关性。方法：对115例乳腺癌患者采用汉密尔顿抑郁量表（HAMD）评定其抑郁症状,生活事件量表（LES）、应对方式问卷、社会支持量表评价其社会心理特征。运用PCR检测115例乳腺癌患者及51例正常对照女性的5-HTTLPR基因多态性。结果：（1）115例乳腺癌患者中合并抑郁症为31例,占27%。（2）115例乳腺癌患者中5-HTTLPR三种基因型HAMD总分比较,差异有显著性（P=0.000）。（3）经多元逐步回归分析,5-HTTLPR基因多态性、家庭成员关系、社会支持总分影响乳腺癌患者HAMD总分。结论：5-HTTLPR基因多态性、家庭成员关系和社会支持总分是乳腺癌患者产生抑郁症状及抑郁严重程度的影响因素。

Association of social psychic factors and 5-HTTLPR gene polymorphism with depressive symptoms in breast cancer patients

Objective：To investigate the association of serotonin transporter gene-linked polymorphic region（5-HTTLPR） and social psychic factors with the morbidity and the serious degree of depressive symptoms in breast cancer patients who were regarded as the individuals with stressful experiences.Methods：In 115 patients with breast cancer,the morbidity and the serious degree of depressive symptoms were assessed with Hamilton depression rating scale（HAMD）.Life event scale（LES）,coping styles questionnaire,social support rating scale were adopted to measure the social-psychological characteristics of breast cancer patients.Polymerase chain reaction technique was used to detect the polymorphism of 5-HTTLPR in 115 breast cancer patients and 51 female controls.Results：There were 31 breast cancer patients with depressive symptoms in 115 breast cancer patients,accounting for 27%.The total score of HAMD was significant different in breast cancer patients with different 5-HTTLPR genotypes（P=0.000）.Multiple stepwise regression analysis showed that there were three factors that had close relationship with the total score of HAMD.They were 5-HTTLPR polymorphism,the relationship among family members,the total score of social support.Conclusion：5-HTTLPR polymorphism,the relationship among family members,the total score of social support was associated with the morbidity and the serious degree of depressive symptoms in breast cancer patients.