| 2-羟基-1-萘酚醛缩邻氨基酚配合物的合成、表征及与ct-DNA的相互作用 |
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| 引用本文： | 杨欢春,杨天林,王丽娟.2-羟基-1-萘酚醛缩邻氨基酚配合物的合成、表征及与ct-DNA的相互作用[J].宁夏大学学报(自然科学版),2009,30(4). |
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| 作者姓名： | 杨欢春 杨天林 王丽娟 |
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| 作者单位： | 1. 宁夏大学,能源化工重点实验室,宁夏,银川,750021;宁夏疾病预防控制中心,宁夏,银川,750004
2. 宁夏大学,能源化工重点实验室,宁夏,银川,750021 |
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| 基金项目： | 教育部科学技术研究重点基金资助项目，宁夏高等学校科学研究基金资助项目 |
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| 摘 要： | 合成了2-羟基-1-萘酚醛缩邻氨基酚(L)配合物,通过红外光谱、紫外光谱、元素分析、摩尔电导率及差热-热重分析,对此化合物进行了结构表征,配合物组成为MLM=Co(Ⅱ),Ni(Ⅱ),Cu(Ⅱ),Zn(Ⅱ)].在pH=7.22的Tris-HCl缓冲溶液中,采用紫外光谱、荧光光谱和黏度法研究了2-羟基-1-萘酚醛缩邻氨基酚配合物与ct-DNA的相互作用,结果表明,该化合物以插入式与ct-DNA键合.
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| 关 键 词： | 希夫碱 配合物 ct-DNA 插入作用 |
Synthesis,Characterization and Interaction with ct-DNA of Schiff Base Condensed from 2-Hydroxy-1-naphthalde-hyde with o-Am Inophenol and Its Complexes |
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| Yang Huanchun,Yang Tianlin,Wang Lijuan.Synthesis,Characterization and Interaction with ct-DNA of Schiff Base Condensed from 2-Hydroxy-1-naphthalde-hyde with o-Am Inophenol and Its Complexes[J].Journal of Ningxia University(Natural Science Edition),2009,30(4). |
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| Authors: | Yang Huanchun Yang Tianlin Wang Lijuan |
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| Affiliation: | 1(1.Key Laboratory of Energy Resources and Chemical Engineering; Ningxia University; Yinchuan 750021; China; 2.Ningxia Centers for Diseases Prevention and Control; Yinchuan 750004; China); |
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| Abstract: | The Schiff base (L) condensed from 2-hydroxy-1-naphthalde-hyde with o-Am inophenol and its complexes are synthesized, and its structure has been characterized which is MLM=Co(Ⅱ),Ni(Ⅱ),Cu(Ⅱ),Zn(Ⅱ)] by IR, UV, TG-DTA, the elements analysis and the molar conductance analysis. The interaction between the complexes and ct-DNA has been studied by electronic absorption spectroscopy, fluorescence, and the viscosity measurement in buffer solution of Tris-HCl(pH=7.22). All of the results indicate that the interaction of the complexes with ct-DNA is intercalation. |
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| Keywords: | ct-DNA Schiff base complex ct-DNA intercalation |
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