EQ-5D和SF-6D测量同期健康效用值的比较研究

目的:比较EQ-5D和SF-6D两个量表的适用性,为药物经济学评价过程中效用值测量工具的选择提供参考。方法:基于已有文献,从效用均值的分布、差异、可交换性及适用性、敏感性分析四个方面,对两个量表进行比较。结果:EQ-5D的效用均值略呈左偏分布,SF-6D较符合正态分布;两个量表在不同分段的效用均值存在差异,一致性较差。结论:两个量表不具有可互换性,在应用过程中应充分考虑两者差异,根据疾病特点选择合适的量表,SF-6D多适用于进程缓慢的疾病,EQ-5D多适用于测量较差的健康状态。

Comparative Study of EQ-5D and SF-6D in Measuring Health Utility Value over the Same Period

Objective To compare the applicability of EQ-5D and SF-6D scales,and to provide a reference for the selection of utility value measurement tools in the process of pharmacoeconomic evaluation.Methods Based on the existing literature,the two scales were compared from the four aspects of the distribution,difference,exchangeability and applicability,and sensitivity analysis of the utility mean.Results The utility mean of EQ-5D showed a slightly leftward distribution,and SF-6D conformed to the normal distribution.The utility mean of the two scales in different segments was different,and the consistency was poor.Conclusion The two scales are not interchangeable.In the application process,the differences between the two should be fully considered.We should select the appropriate scale according to the characteristics of the disease.SF-6D is mostly suitable for slow-moving diseases,and EQ-5D is mostly suitable for measuring poor health.