槲皮素的文献计量学及可视化分析

目的]采用文献计量学的研究方法,通过CiteSpace软件对槲皮素相关的文献进行可视化分析,发掘该研究领域近年来的研究热点、前沿动态和发展趋势。方法]分析了2000年至2017年期间,Science Citation Index Expanded(SCI-E)数据库中槲皮素相关的研究文献,应用CiteSpace软件进行作者、国家、机构的合作网络分析,关键词的共现分析,作者、文献、期刊的共被引分析,并绘制相关可视化图谱。结果]通过检索共获得19 795篇文献,发文量接近每年1164篇。高产国家主要为中国和美国;机构分析显示中国科学院和圣保罗大学发文量较多,高达270篇和220篇。发表槲皮素相关文献的主要期刊为Journal of Agricultural and Food Chemistry和Food Chemistry等。研究热点主要体现在槲皮素的抗氧化活性方面,近五年对槲皮素抗氧化分子药理通路的研究和纳米粒方向的研究文献报道较多。结论] CiteSpace软件的分析结果表明,槲皮素抗氧化活性的药理学分子机制研究及药剂学纳米制剂研究是该领域的研究热点以及未来可能的发展方向,这对槲皮素的深入研究和未来研究选题具有一定的参考意义。

Bibliometrics and visual analysis of quercetin

Objective] This paper adopted research methods of bibliometrics to conduct a visual analysis of literatures related to quercetin through CiteSpace software to explore the research hotspots, frontiers dynamics and development trends in recent years.Methods] Research literatures related to quercetin in the Science Citation Index Expanded (SCI-E) database from 2000 to 2017 were analyzed. The cooperation network analysis of authors, countries and regions and institutions was conducted with CiteSpace. Co-occurrence analysis of keywords, co-citation analysis of authors, literatures and periodicals were conducted with CiteSpace. And then relevant visualization maps were drawn.Results] A total of 19 795 articles were retrieved, with nearly 1 164 articles each year. The most productive countries and regions were China and the United States. Institutional analysis showed that the Chinese Academy of Sciences and the University of São Paulo publish more papers, up to 270 and 220. The main publications of quercetin were Journal of Agricultural and Food Chemistry and Food Chemistry. The research focus was mainly on the antioxidant activity of quercetin. In the past five years, there had been many reports on the research on the molecular pharmacological pathway of the antioxidant of quercetin and on the nanoparticles research of quercetin.Conclusion] The results of CiteSpace software analysis showed that the research on the pharmacological molecular mechanism of quercetin antioxidant activity and on the pharmaceuticals nano-preparations are the research hotspots and the possible development direction in the future. These results will have certain reference significance for the in-depth study of quercetin and future research selected topic.