| Mechanical Studies on Treatment of Malignant Tumour by Ultralow Frequency Pulsed-Gradient Magnetic Fields |
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| 作者姓名： | Deng Ren-qing Liu Qing-hua Zhang Hu-sheng
College of Physical Science and Technology Wuhan University Wuhan Hubei China |
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| 作者单位： | Deng Ren-qing，Liu Qing-hua Zhang Hu-sheng
College of Physical Science and Technology，Wuhan University，Wuhan 430072，Hubei，China;
Department of electric and computer engineering，National University of Singapore，Singapore 119260，Singapore |
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| 基金项目： | the National Natural Science Foundation of China(39870823)and the Ministry of Science and Technology of China |
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| 摘 要： | Ultralow frequency (ULF) pulsed-gradient magnetic field (with the maximum intensity of 0.6-2.0 T, gradient of 10-100 T·m-1, pulse width of 20-200 ms and frequency of 0. 16-1. 34 Hz) treatment of mice can inhibit murine malignant tumour growth and can induce apoptosis of cancer cell. The apoptotic cancer cell contracted, became rounder and divorced from adjacent cells; the heterochromatin condensed and coagulated together along the inner side of the nuclear membrane; the endoplasmic reticulums expanded and fused with the cellular membrane; many apoptotic bodies which were packed by the cellular membrane appeared and were devoured by some lymphocytes and plasma. By Lorentz force the magnetic field keeps the moving ions within bounds of Larmor radius. Thus, penetrating capability of the positive and negative ions through the cell membrane was affected, even the role on the cell membrane formed.
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Mechanical studies on treatment of malignant tumour by ultralow frequency pulsed-gradient magnetic fields |
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| Deng Ren-qing,Liu Qing-hua Zhang Hu-sheng
College of Physical Science and Technology,Wuhan University,Wuhan ,Hubei,China,.Mechanical Studies on Treatment of Malignant Tumour by Ultralow Frequency Pulsed-Gradient Magnetic Fields[J].Wuhan University Journal of Natural Sciences,2003,8(2):463-466. |
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| Authors: | Deng Ren-qing Liu Qing-hua Zhang Hu-sheng |
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| Affiliation: | (1) College of Physical Science and Technology, Wuhan University, 430072 Wuhan, Hubei, China;(2) Department of electric and computer engineering, National University of Singapore, 119260 Singapore, Singapore |
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| Abstract: | Ultralow frequency (ULF) pulsed-gradient magnetic field (with the maximum intensity of 0. 6-2. 0 T,gradient of 10-100 T @ m-1 , pulse width of 20-200 ms and frequency of 0. 16-1. 34 Hz) treatment of mice can inhibit murine malignant tumour growth and can induce apoptosis of cancer cell. The apoptotic cancer cell contracted, became rounder and divorced from adjacent cells; the heterochromatin condensed and coagulated together along the inner side of the nuclear membrane; the endoplasmic reticulums expanded and fused with the cellular membrane; many apoptotic bodies which were packed by the cellular membrane appeared and were devoured by some lymphocytes and plasma. By Lorentz force the magnetic field keeps the moving ions within bounds of Larmor radius. Thus, penetrating capability of the positive and negative ions through the cell membrane was affected,even the role on the cell membrane formed. |
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| Keywords: | magnetic field cancer apoptosis role on cell membrane |
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