冠脉狭窄对外周与中心动脉间传递函数的影响

观察冠脉狭窄患者中心动脉波的变化，并探讨外周与中心动脉间的传递函数与冠脉狭窄的相关性.采集了9名冠脉狭窄患者支架手术前后的中心动脉与桡动脉脉搏波，分别建立手术前后的自回归传递函数数学模型，并将手术后的桡动脉波形分别用手术前后的传递函数模型重建中心动脉波形.提取两中心动脉波形的特征点并计算重建出的两中心动脉压的特征参数K，t，接着分别与术后实测中心动脉压的参数进行显著性差异分析.实验结果表明，冠状动脉狭窄对传递函数存在着一定的影响，在临床上的意义为对于急性心梗患者在急性患病时间内不能用通用传递函数重建中心动脉.

Influence of Coronary Artery Stenosis on Transfer Function Between Peripheral and Central Arteries

To observe the changes of central artery wave and explore the correlation between transfer function of peripheral and central artery and coronary artery stenosis in patients. Center artery and radial artery pulse wave before and after stent surgery from 9 patients with coronary artery stenosis were collected. ARX(auto-regressive with extra inputs) transfer function before and after stent surgery were established. Radial artery waveform after surgery was reconstructed with the transfer function model before and after surgery. Characteristic points of the two central arterial waveforms were extracted and the characteristic parameters K and t of the reconstructed two central arterial pressure were calculated. And then， the significant difference analysis of the measured central arterial pressure parameters was analyzed. The experimental results indicated that coronary artery stenosis has a certain impact on the transfer function， and clinical significance of the acute myocardial infarction in patients with acute illness cannot be reconstructed with a common transfer function of the central artery.