| 高锰酸钾褪色分光光度法测定泛昔洛韦 |
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| 引用本文： | 战宏伟,刘英红. 高锰酸钾褪色分光光度法测定泛昔洛韦[J]. 淮海工学院学报, 2012, 0(2): 44-46 |
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| 作者姓名： | 战宏伟 刘英红 |
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| 作者单位： | [1]江苏绿源工程设计研究有限公司,江苏连云港222003 [2]淮海工学院化学工程学院,江苏连云港222005 |
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| 摘 要： | 采用高锰酸钾褪色分光光度法测定泛昔洛韦。在硫酸介质中，高锰酸钾能够氧化泛昔洛韦而使自身颜色发生明显变化，且吸光度的变化值与泛昔洛韦的浓度呈线性关系。在测定波长525nm处，泛昔洛韦的浓度在2×10^-5-7x10^-4mol·L^-1范围内符合比尔定律。方法的检出限为3．8×1O^-6mol·L^-1将该方法用于药物制剂和尿液中是昔洛韦浓度的测定，结果令人满意。
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| 关 键 词： | 高锰酸钾 泛昔洛韦 褪色分光光度法 |
Fading Spectrophotometric Determination of Famciclovir by Potassium Permanganate Method |
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| ZHAN Hong-wei,LIU Ying-hong. Fading Spectrophotometric Determination of Famciclovir by Potassium Permanganate Method[J]. Journal of Huaihai Institute of Technology:Natural Sciences Edition, 2012, 0(2): 44-46 |
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| Authors: | ZHAN Hong-wei LIU Ying-hong |
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| Affiliation: | 1. Jiangsu Lǜiyuan Engineering Design Research Co. Ltd. , Lianyungang 222003, China; School of Chemical Engineering, Huaihai Institute of Technology, Lianyungang 222005, China) |
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| Abstract: | The determination of famciclovir was carried out by spectrophotometry based on the discoloration of potassium permanganate. It was found that the discoloration of potassium per- manganate caused by the famciclovir reduction in H2SO4 medium was proportional,to the amount of famciclovir. The concentration of famciclovir in the range of 2 ×10^-5-7 × 10^-4 mol· L^-1 o- beyed Beer＇s law at the wavelength of 525 nm. The detection limit of this method was 3.8 × 10^-6 tool - L^-1. The method was used in the determination of famciclovir in medicine samples and hu- man urine with satisfactory results. |
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| Keywords: | potassium permanganate famciciovir spectrophotometry |
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