In vitro antifungal activity of amphotericin B and 11 comparators against Aspergillus terreus species complex |
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| Authors: | Afsane Vaezi Hamed Fakhim Amir Arastehfar Tahereh Shokohi Mohammad T Hedayati Sadegh Khodavaisy Ali Rezaei‐Matehkolaei Parisa Badiee Ferry Hagen Cornelia Lass‐Flörl Eric Dannaoui Jacques F Meis Hamid Badali |
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| Affiliation: | 1. Department of Medical Mycology and Parasitology, Invasive Fungi Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran;2. Student Research Committee Center, Mazandaran University of Medical Sciences, Sari, Iran;3. Department of Medical Parasitology and Mycology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran;4. Cellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran;5. Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands;6. Department of Medical Mycology and Parasitology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran;7. Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;8. Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;9. Department of Medical Microbiology and Infectious Diseases, Canisius‐Wilhelmina Hospital (CWZ), Nijmegen, The Netherlands;10. Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria;11. Faculté de Médecine, APHP, Université Paris‐Descartes, H?pital Européen Georges Pompidou, Unité de Parasitologie‐Mycologie, Paris, France;12. Center of Expertise in Mycology Radboudumc, CWZ, Nijmegen, The Netherlands |
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| Abstract: | Aspergillus terreus infections are difficult to treat because of the intrinsic resistance to amphotericin B, and higher mortality compared to infections caused by other Aspergillus species. The aim of the present study was to determine the in vitro antifungal activity of amphotericin B and 11 comparators against clinical (n = 36) and environmental (n = 45) A. terreus isolates. In vitro antifungal susceptibility was performed using the CLSI M38‐A2 procedure. Amphotericin B exhibited the highest MICs (MIC range, 0.125‐4 μg/mL; MIC90, 2 μg/mL), followed by terbinafine (MIC range, 0.002‐1 μg/mL; MIC90, 1 μg/mL). Only one isolate (1/81) showed amphotericin B MIC above the epidemiologic cut‐off value (ECV; 4 μg/mL). None of the isolates had a MIC of ≥ ECV for voriconazole, itraconazole and posaconazole. The reasons for the difference in amphotericin B susceptibility patterns between studies remain unknown. The genetic and species diversity, clinical, environmental and ecological factors in Terrei section on various amphotericin B susceptibility profiles in different countries should be considered more as the main reasons associated with these differences. |
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| Keywords: | amphotericin B Aspergillus terreus species complex In vitro antifungal activity Iran |
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