| 线粒体作为放射损伤防治靶点的研究进展 |
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| 引用本文： | 冉曦,杜长虹.线粒体作为放射损伤防治靶点的研究进展[J].中华放射医学与防护杂志,2022,42(9):727-730. |
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| 作者姓名： | 冉曦 杜长虹 |
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| 作者单位： | 陆军军医大学第二附属医院检验科, 重庆 400037;陆军军医大学军事预防医学系全军复合伤研究所, 重庆 400038 |
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| 基金项目： | 国家自然科学基金(81874256) |
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| 摘 要： | 电离辐射会导致蛋白质、DNA等生物大分子损伤,以致细胞癌变、凋亡、衰老等一系列变化。放射损伤后,有效防治靶点的缺乏又致可用治疗药物种类十分有限。新近研究提示,线粒体在放射损伤中发挥重要作用,并有望成为新的防治靶点。本研究就电离辐射对线粒体的影响,特别是氧化应激的发生,以及线粒体在电离辐射诱导生物损伤效应中的作用进行综述,旨在讨论将线粒体作为潜在的放射损伤防治靶点的可行性。
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| 关 键 词： | 放射损伤 线粒体 氧化应激 放射防护 |
| 收稿时间： | 2022/5/5 0:00:00 |
Research progress of mitochondria as a key target for radioprotection |
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| Ran Xi,Du Changhong.Research progress of mitochondria as a key target for radioprotection[J].Chinese Journal of Radiological Medicine and Protection,2022,42(9):727-730. |
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| Authors: | Ran Xi Du Changhong |
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| Affiliation: | Department of Medical Laboratory, Second Affiliated Hospital, Army Military Medical University, Chongqing 400037, China; Institute of Combined Injury, College of Preventive Medicine, Army Military Medical University, Chongqing 400038, China |
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| Abstract: | Ionizing radiation can cause damage to biological macromolecules such as DNA and protein,resulting in a series of biological changes such as carcinogenesis,apoptosis and aging.However,after radiation injury,the lack of effective prevention and treatment targets leads to the limited variety of available therapeutic drugs.Recent studies suggest that mitochondria play an important role in radiation injury and are expected to become a new prevention and treatment target.This paper reviewed the effects of ionizing radiation on mitochondria,especially the occurrence of oxidative stress,and the role of mitochondria in radiation-induced biological effects,in order to discuss the feasibility of mitochondria as a potential target for radiation damage prevention and treatment. |
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| Keywords: | Radiation injury Mitochondria Oxidative stress Radioprotection |
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