VEGF和VEGF-C表达增加与前列腺癌进展的相关性研究

目的探讨前列腺癌(PCa)组织及癌周正常组织中血管内皮细胞生长因子(VEGF)、血管内皮细胞生长因子C(VEGF-C)表达与PCa进展的相关性。方法采用SABC免疫组化染色法对71例PCa组织标本中CD34、VEGF及VEGF-C的表达进行检测,并对所获得的数据进行统计分析。结果与癌周正常组织相比,PCa上皮/肿瘤细胞内VEGF和VEGF-C表达显著上调(P<0.01)。Jewett-Whitmore分期D期癌灶内VEGF-C表达显著高于A、B或C期患者(P<0.01)。Jewett-Whitmore分期与VEGF-C(rs=0.738,P<0.001)、MVD与VEGF(rs=0.492,P<0.001)之间存在显著的相关性。结论VEGF和VEGF-C表达增加与PCa的进展密切相关。VEGF促进肿瘤组织内部微血管形成,而VEGF-C的主要作用在于促进淋巴管形成。

Increased expressions of VEGF and VEGF-C in prostate cancer tissue are associated with tumor progression

Objective To investigate the expressions of VEGF and VEGF-C between PCa tissues and adjacent benign tissues, and explore the roles of VEGF and VEGF-C in the progression process of PCa. Methods Seventy-one primary prostatic adenocarcinoma cases were included in this study and an immunohistochemical approach was adopted to detect the expressions of CD34, VEGF and VEGF-C in each sample. Then a statistic analysis was performed according to the experimental data. Results Significantly up-regulated expressions of VEGF and VEGF-C were both found in malignant epithelium/cancer cells compared with adjacent benign epithelium(P<0.01, respectively). Patients in stage D had a significantly higher score than patients in stage A, B or C when comparing VEGF-C expression in tumor area(P<0.01). In addition, significant correlations were observed between Jewett-Whitmore staging and VEGF-C(rs=0.738, P<0.001), and MVD and VEGF(rs=0.492, P<0.001). Conclusions Increased expressions of VEGF and VEGF-C were closely associated with progression of prostate cancer. The main contribution of VEGF for PCa progression was to stimulate angiogenesis, while the chief role of VEGF-C was to enhance lymphangiogenesis.