| 新型硫代乙酰胺为桥基的噻唑三唑类化合物的合成及抑菌活性 |
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| 引用本文： | 高海燕,卢俊瑞,辛春伟,鲍秀荣,冯钟念,董双双.新型硫代乙酰胺为桥基的噻唑三唑类化合物的合成及抑菌活性[J].天津理工大学学报,2012,28(2):39-42,53. |
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| 作者姓名： | 高海燕 卢俊瑞 辛春伟 鲍秀荣 冯钟念 董双双 |
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| 作者单位： | 天津理工大学化学化工学院,天津,300384 |
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| 基金项目： | 国家自然科学基金，天津市高校科技发展基金 |
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| 摘 要： | 本文以具有良好生物活性的1,3,4-噻二唑、1,2,4-三唑为先导物,通过化学修饰合成了4种同时含有1,3,4-噻二唑、1,2,4-三唑、酰胺和硫醚片断的新型目标化合物,并利用1HNMR、IR进行了结构表征.抑菌测定表明:目标化合物对大肠杆菌,白色念珠菌的抑菌率均达84%以上,尤其是对金黄色葡萄球菌的抑菌活性高达90%以上,具有强抑菌活性.
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| 关 键 词： | 1 2 4-三唑 1 3 4-噻二唑 合成 构效关系 |
Synthesis and antibacterial activities of novel thioacetamide derivatives containing triazole and thiazole ring |
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| GAO Hai-yan
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LU Jun-rui
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XIN Chun-wei
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BAO Xiu-rong
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FENG Zhong-nian
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DONG Shuang-shuang.Synthesis and antibacterial activities of novel thioacetamide derivatives containing triazole and thiazole ring[J].Journal of Tianjin University of Technology,2012,28(2):39-42,53. |
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| Authors: | GAO Hai-yan LU Jun-rui XIN Chun-wei BAO Xiu-rong FENG Zhong-nian DONG Shuang-shuang |
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| Affiliation: | (School of Chemistry and Chemical Engineering,Tianjin University of Technology,Tianjin 300384,China) |
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| Abstract: | In this paper,four novel compounds which simultaneously possess 1,2,4-triazole,1,3,4-thiadiazole,amide,and sulfide fragments were designed and synthesized through chemical modification by using 1,2,4-triazole and 1,3,4-thiadiazole as the lead compounds.The structures have been characterized by 1H NMR and IR.The preliminary bioassay which is more than 85% inhibitory rate against Escherichia coli and Monilia albicans and is over 90% against Staphylococcus aureus at 0.01% mass concentration.Indicates that the target compounds possess a stronger antibacterial activity. |
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| Keywords: | 1 2 4-triazole 1 3 4-thiadiazole synthesis structure-activity relationship |
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