| OPN和B7-H4在上皮性卵巢肿瘤中的表达及意义 |
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| 引用本文： | 张丽丽,邵淑丽,武燕.OPN和B7-H4在上皮性卵巢肿瘤中的表达及意义[J].癌症,2010,29(1):25-29. |
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| 作者姓名： | 张丽丽 邵淑丽 武燕 |
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| 作者单位： | 山西医科大学第二临床医学院;山西省肿瘤医院妇科; |
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| 摘 要： | 背景与目的:上皮性卵巢癌的发生涉及多方面的因素。近年的研究表明骨桥蛋白(osteopontin,OPN)与多种肿瘤的发生发展有关,但其在卵巢癌中的研究较少;而B7-H4是新近发现的肿瘤标志物,其在卵巢癌中的研究也很少。本研究旨在探讨卵巢上皮性肿瘤中OPN和B7-H4的表达及其临床意义。方法:采用免疫组化法检测15例正常卵巢组织、20例卵巢良性肿瘤组织、20例卵巢交界性肿瘤组织、40例卵巢癌组织标本中OPN和B7-H4的表达情况,分析两者表达与卵巢癌临床病理特征的关系。结果:OPN和B7-H4在上皮性卵巢癌组织中的表达高于卵巢交界性及良性、正常卵巢组织,各组之间的差异有统计学意义(P<0.05)。OPN和B7-H4在低分化卵巢癌中的阳性率均显著高于高、中分化卵巢癌(P<0.05),Ⅲ～Ⅳ期卵巢癌中的阳性率亦显著高于Ⅰ～Ⅱ期卵巢癌(P<0.05)。OPN阳性者伴有较高的淋巴结转移率(P<0.05),而与年龄、组织学类型无关;B7-H4在卵巢浆液性癌中的阳性率显著高于黏液性癌(P<0.05),而与年龄、淋巴结转移等无关。结论:OPN、B7-H4在上皮性卵巢癌中表达升高,可为卵巢恶性肿瘤的诊断提供参考。
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| 关 键 词： | 骨桥蛋白 B7-H4 卵巢癌 上皮性肿瘤 免疫组化 |
Expressions of osteopontin and B7-H4 in epithelial ovarian neoplasm and their significance |
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| Li-Li Zhang, Shu-Li Shao , Yan Wu.Expressions of osteopontin and B7-H4 in epithelial ovarian neoplasm and their significance[J].Chinese Journal of Cancer,2010,29(1):25-29. |
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| Authors: | Li-Li Zhang Shu-Li Shao Yan Wu |
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| Affiliation: | Li-Li Zhang,1 Shu-Li Shao2 , Yan Wu21.The Second Clinical Hospital of Shanxi Medical University,Taiyuan,030001,Shanxi,P.R.China 2.Department of Gynecology,Shanxi Provincial Cancer Hospital,030013,P.R.China |
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| Abstract: | Background and Objective:Epithelial ovarian cancer involved a number of factors.Recent studies have shown that osteopontin (OPN) was related to carcinogenesis and development of a variety of tumors,but few studies on ovarian cancer were reported.B7-H4 is a newly identified tumor marker in ovarian cancer.This study was to explore the expressions of OPN and B7-H4 and their clinical significance in epithelial ovarian tumors.Methods:The expressions of OPN and B7-H4 in 15 cases of normal ovarian tissue,20 benign... |
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| Keywords: | osteopontin B7-H4 ovarian carcinoma epithelial neoplasm immunohistochemistry |
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