丙型肝炎疫苗的研究进展

丙型肝炎是由丙型肝炎病毒(HepatitisCvirus,HCV)感染而引起的严重威胁人类健康的传染病,目前还没有研制成功有效的预防性疫苗,HCV基因组的高度变异及缺乏易感动物模型一直是妨碍丙肝疫苗发展的瓶颈。随着对HCV免疫清除机制的逐渐认识,诱导交叉反应性中和抗体和细胞免疫应答已成为丙肝疫苗研究的基本方向。本文概述了免疫应答在控制HCV感染过程中的作用以及当前丙肝疫苗的研究策略,并分析了丙肝疫苗的发展前景。

Recent advances in hepatitis C vaccine

Hepatitis C, caused by hepatitis C virus (HCV), is an important infectious disease threatening human health, and at present, there are no vaccines available for preventing HCV infection. The major obstacle in the vaccine development is concerned with the high variability of HCV genome and the lack of a suitable and economical animal model. An effective vaccine against HCV should be capable of inducing broad cross-reactive neutralizing antibodies and strong cellular immune responses. In this review we described the immune response essential for clearance of HCV infection, the present vaccine strategies, and the tactics that may be useful in future vaccine design.