阻塞性睡眠呼吸暂停低通气综合征与血脂水平相关性的meta分析

目的系统评价阻塞性呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)与血脂水平的相关性,探讨OSAHS患者血脂水平变化的临床意义。方法计算机检索PubMed、Cochrane Library、中国学术期刊全文数据库(CNKI)、维普网、万方数据库,对纳入文献和相关综述的参考文献进行手工检索,查找公开发表的有关OSAHS与血脂水平相互关系的病例对照研究,检索时限均为建库至2018年12月。由2位研究者独立进行筛选、提取资料和评价偏倚风险后,采用RevMan5.3软件进行meta分析。结果通过筛选,总共纳入9个研究,包括1473个患者。Meta分析结果显示,OSAHS患者的甘油三酯MD=0.60,95%CI(0.54,0.67),P<0.01]及低密度脂蛋白MD=0.25,95%CI(0.02,0.49),P<0.01]水平高于对照组,高密度脂蛋白MD=-0.17,95%CI(-0.25,-0.08),P<0.01]水平低于对照组。结论Meta分析结果表明,OSAHS患者常合并有血脂异常,然而,因为受纳入研究数量及研究质量的限制,上述结论及相关机制仍需更高质量及更大样本的试验研究进一步验证。

Meta-analysis of the relationship between obstructive sleep apnea hypopnea syndrome and serum lipid levels

Objective To systematically evaluate the correlation between obstructive sleep apnea hypopnea syndrome(OSAHS)and serum lipid levels,and to explore the clinical significance of changes in serum lipid levels of OSAHS patients.Methods PubMed,Cochrane Library,CNKI,VIP and Wanfang database were searched.The literatures and references enrolled were manually searched to find the published case-control studies on the relationship between OSAHS and serum lipid levels.The retrieval time was from the establishment of the database to December 2018.Meta-analysis was conducted with revman5.3 software after screening,extracting data and evaluating the risk of bias by two researchers independently.Results A total of 9 studies including 1473 patients,were enrolled in the screening.The results of meta-analysis showed that triglycerides(MD=0.60,95%CI0.54,0.67],P<0.01)and low-density lipoprotein levels(MD=0.25,95%CI0.02,0.49],P<0.01)in OSAHS patients were higher than those in control group,while the level of high-density lipoprotein(MD=-0.17,95%CI-0.25,-0.08],P<0.01)was lower than that in the control group.Conclusion The results of meta-analysis indicate that patients with OSAHS often have dyslipidemia.However,due to the limited number of studies and the quality of them,the above conclusions and related mechanisms still require experimental research with higher quality and larger samples to further verify.