| 毛细支气管炎免疫机理及干扰素疗效研究 |
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| 引用本文： | 刘文彬,罗琼,朱贵红,王军.毛细支气管炎免疫机理及干扰素疗效研究[J].西南国防医药,1997(2). |
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| 作者姓名： | 刘文彬 罗琼 朱贵红 王军 |
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| 作者单位： | 解放军60医院成都军区儿科中心，解放军60医院成都军区儿科中心，解放军60医院成都军区儿科中心，解放军60医院成都军区儿科中心 云南大理 671003，云南大理 671003，云南大理 671003，云南大理 671003 |
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| 摘 要： | 本文测定50例毛细支气管炎患儿T淋巴细胞亚群,同时观察干扰素(INF)治疗前后的变化并判定临床疗效,结果表明急性期呼吸道合胞病毒毛细支气管炎患儿CD_8细胞明显升高,CD_4/CD_8比值明显降低(P<0.01),CD_3、CD_4细胞与正常对照组比较无明显差异(P>0.05);INF治疗后CD_8细胞显著降低,CD_4/CD_8比值明显升高(P<0.01);且临床疗效及病程均明显优于未用INF组。作者对本病发病机理及INF作用机制进行了讨论。
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| 关 键 词： | 呼吸道合胞病毒 毛细支气管炎 T淋巴细胞亚群 干扰素 |
MECHANISM OF IMMUNOLOGY OF BRONCHILITIS AND OBSERVATION OF TREATMENTAL EFFECTS OF INTERFERON |
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| Liu Wenbing,Luo Qiong,Zhu Gui-hong,Wang Jun The Center of pediatrics of Chengdu Military Command,Army Hospital of PLA,Dali,..MECHANISM OF IMMUNOLOGY OF BRONCHILITIS AND OBSERVATION OF TREATMENTAL EFFECTS OF INTERFERON[J].Medical Journal of National Defending forces in Southwest China,1997(2). |
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| Authors: | Liu Wenbing Luo Qiong Zhu Gui-hong Wang Jun The Center of pediatrics of Chengdu Military Command Army Hospital of PLA Dali |
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| Affiliation: | Liu Wenbing,Luo Qiong,Zhu Gui-hong,Wang Jun The Center of pediatrics of Chengdu Military Command,Army Hospital 60 of PLA,Dali,67100. |
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| Abstract: | The varieties of number of the eymphocytic subtypes of 50 children with the bronchioli-tis and the treatmental effects of interferon were observed. The results showed that during the acute period of the bronchiolitis induced by the respiratory syncytial virus, the number of CDS of these cases increased and the ratio of CD4/CD8 decreased very significantly (p<0. 01). But the number of CDS and CD4 of these ones were similar to those of the normal children. After the treatment with interteron , the number of CD8 of the patients decreased and the ratio of CD4/CD8 increased remarkably (p<0. 01) and the clinical effects was better and the ill period was shorter .compared with the patients who were treated without interferon. |
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| Keywords: | respiratory syncytial virus bronchiolitis lymphocytic subtype interferon |
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