A型肉毒毒素在神经系统疾病中的应用研究进展

近年来随着A型肉毒毒素作用机制研究的不断深入，其在神经系统疾病中的应用范围日渐扩大。因其肌肉化学性去神经支配效应可用于治疗面肌痉挛、特发性眼睑痉挛、口下颌肌张力障碍、痉挛性斜颈、抽动障碍、脑卒中后肢体痉挛和痉挛性脑瘫；因其植物神经系统效应可用于治疗多涎病症和多汗证；因其镇痛效应可用于治疗各种头痛和神经痛，故A型肉毒毒素已逐渐成为神经科领域一种重要的治疗手段。

Application progress of botulinum toxin type A in the nervous system diseases

In recent years,with the deepening study on the mechanism of botulinum toxin type A,the range of its applications in the nervous system diseases continues to expand.Because botulinum toxin type A produces partial chemical denervation of the muscle resulting in a localized reduction in muscle activity,it can be used to treat hemifacial spasm,idiopathic blepharospasm,oromandibular dystonia,spasmodic torticollis,tic disorder,limb spasticity after stroke and spastic cerebral palsy.In addition,it has recently be...