中药注射剂不良反应/事件95例的相关因素分析

目的分析中药注射剂不良反应/事件的发生情况及相关因素,为临床合理用药提供参考。方法对该院2006～2008年上报的95例中药注射剂不良反应/事件报告表进行回顾性分析。结果本组不良反应/事件以药物热和皮肤及其附件损害为主,共76例占80.0%;涉及27个注射剂品种,其中冠心宁注射液、银杏达莫注射液、血塞通注射液、生脉注射液、香丹注射液等5种注射剂共诱发63例不良反应/事件占66.3%。结论提倡中药口服途径给药,慎用中药注射剂,加强对中药注射剂不良反应/事件的监测和相关研究,提高临床用药的安全性。

Analysis of 95 Adverse drug reactions/events induced by traditional Chinese medicine injections

Objective The condition and related factors of adverse drug reactions/events induced by traditional Chinese medicine injections are analyzed to provide references for clinical use. Methods 95 adverse drug reactions/events induced by traditional Chinese medicine injections reported from 2006 to 2008 in the hospital have been analyzed retrospectively. Results The main clinical symptoms of 76 cases which account for 80.0% of 95 cases are drug fever and skin and appendages disorders. 95 cases involve 27 injections. 54 cases caused by Guanxinning injection, Yinxingdamo injection, Xuesaitong injection, shengrnai injection and xiangdan injection account for 66.3 % of all cases. Conclusion It is advocated that the tra- ditional Chinese medicine should be taken orally and the use of traditional Chinese medicine injections must be careful. The monitoring of adverse drug reactions/events induced by traditional Chinese medicine injections and related study should be strengthened to improve the clinical safety.