The multiple drug resistance gene,MDR1: Expression at the protein and RNA levels |
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| Authors: | Ya Qin Li Venu Gopal Pratibha Kadam Shawn Files Harvey Preisler |
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| Affiliation: | 1. University of Cincinnati Medical Center, (ML 508), 231 Bethesda Avenue, 45267-0508, Cincinnati, Ohio, USA
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| Abstract: | A comparison of three different approaches to detect MDR1 expression in myeloid leukemia cells was undertaken. With respect to the 4 different antibodies studied, a high proportion of false positive reactions were detected. Substantial discordance between MDR1 expression as indicated by Northern blot analysis, PCR, and immunohistochemistry was found. These findings complicate the clinical interpretation of data derived from these methods. |
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