瑞舒伐他汀钙与氯吡格雷联合治疗不稳定型心绞痛的疗效分析

目的：：探讨瑞舒伐他汀钙与氯吡格雷联合治疗不稳定型心绞痛的临床疗效和安全性。方法：112例不稳定型心绞痛患者，根据治疗方法不同分为对照组和观察组。对照组44例给予低分子肝素、阿司匹林、血管紧张素转换酶抑制剂、硝酸酯类药物、β受体阻滞剂等常规治疗；观察组68例在对照组基础上给予瑞舒伐他汀钙联合氯吡格雷治疗，均治疗4周。观察2组临床疗效及安全性，并对血脂水平及不良反应情况进行监测。结果：观察组心绞痛症状改善总有效率为94.1%，高于对照组的81.8%(P<0.05)；观察组心电图改善总有效率为92.6%，显著高于对照组的77.3%(P<0.01)；2组治疗前血脂水平差异均无统计学意义(P>0.05)，治疗后2组血脂水平均较治疗前明显改善(P<0.01)；且治疗后2组血脂水平相比差异均有统计学意义(P<0.01)。观察组和对照组总不良反应发生率分别为2.9%与13.6%，差异无统计学意义(P>0.05)。随访期间，观察组心绞痛再发率低于对照组(P<0.05)。结论：在常规治疗基础上，瑞舒伐他汀钙与氯吡格雷联合治疗不稳定型心绞痛的临床疗效好，安全性高，值得临床应用。

Curative effects analysis of using rosuvastatin calcium combined with clopidogrel to treat unstable angina pectoris

Objective:To explore the curative effects and clinical safety of rosuvastatin calcium combined with clopidogrel in the treatment of unstable angina pectoris( UAP) . Methods:One hundred and twelve patients with UAP were divided into the control group (44 cases) and observation group(68 cases) according to different therapeutic methods. The control group and observation group were treated with low molecular heparin,aspirin,angiotensin converting enzyme inhibitors,nitrates and beta blockers and rosuvastatin calcium combined with clopidogrel based on the control group treatment,respectively. The clinical curative effects,safety,blood lipid level and adverse reactions in two groups were monitored. Results:The total effective rate in observation group(94. 1%) was higher than that in control group(81. 8%) (P < 0. 05). The effective rate of electrocardiogram improvement in observation group(92. 6%) was significantly higher than that in control group(77. 3%) (P<0. 01). The difference of the blood lipid level between two groups before treatment was not statistically significant (P >0. 05),the blood lipid level in observation group after treatment was improved(P <0.01),and the difference of the blood lipid level between two groups after treatment was statistically significant (P <0. 01). The incidences of adverse reactions in control group and observation group were 2. 9% and 13. 6%,respectively,the difference of which was not statistically significant (P>0. 05). During the following-up period,the angina recurrence rate in observation group were lower than those in controll group(P <0. 05). Conclusions:On the basis of conventional treatment,the rosuvastatin calcium combined with clopidogrel in the treatment of unstable angina pectoris has good effects and high safety,which is worthy of clinical application.